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Comunicazioni Orali
Relationship between plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9), vascular events and markers of subclinical atherosclerosis: results from the IMPROVE study
Daniela Coggi1 , Massimiliano Ruscica1 , Mauro Amato1 , Beatrice Frigerio1 , Daniela Sansaro1 , Alessio Ravani1 , Fabrizio Veglia1 , Alice Bonomi1 , Elena Tremoli1 , Nicola Ferri2 , Damiano Baldassarre1 ( 1 Milan, 2 Padua)
O001
O002
Ultrasound-mediated activity by various metal-porphyrin complexes in human colon cancer and fibroblast cells
Roberto Canaparo1 , Vanessa Pinelli1 , Federica Foglietta1 , Patrizia Panzanelli1 , Gianni Durando1 , Giampiero Muccioli1 , Francesca Giuntini2 , Loredana Serpe1 ( 1 Turin, 2 Liverpool - United Kingdom
O003
In vivo ultrasonographic evaluation of muscle function and structure in animal models of muscular dystrophy and aging sarcopenia: a new approach to assess disease progression and pharmacological efficacy
Antonietta Mele, Paola Mantuano, Francesca Sanarica, Adriano Fonzino, Francesco Rana, Diana Conte, Domenico Tricarico, Annamaria De Luca (Bari)
O005
C-reactive protein and immature platelet fraction contribute to poor responsiveness to low-dose aspirin and persistent in vivo platelet activation in polycythemia vera
Giovanna Petrucci1 , Viviana Cavalca2 , Alfredo Dragani3 , Benedetta Porro2 , Paola Ranalli3 , Elena Tremoli2 , Carlo Patrono1 , Bianca Rocca1 ( 1 Rome, 2 Milan, 3 Pescara)
O006
Role of NF-kappaB/c-Rel in Parkinson’s Disease
Vanessa Porrini1 , Annamaria Lanzillotta1 , Andrea Pilotto1 , Antonella Alberici1 , Alessandro Padovani1 , Angelo Antonini2 , Arianna Bellucci1 , Marina Pizzi1 ( 1 Brescia, 2 Venice)
O007
Enhanced expression of the sphingosine 1-phosphate receptor 3 causes acute myelogenous leukemia in mice
Samuel Vorbach1 , Fengbiao Zhou2 , Albert Gründer1 , Manuela Simoni3 , Laura Riccetti3 , Peter Valk4 , Mathijs Sanders4 , Carsten Müller-Tidow2 , Jerzy-Roch Nofer5 , Heike Pahl1 , Francesco Potì6 ( 1 Freiburg - Germany, 2 Heidelberg - Germany, 3 Modena
O008
Failure of low-dose aspirin to affect enhanced extraplatelet prostanoid biosynthesis in vivo in Familial Adenomatous Polyposis patients
Stefania Tacconelli1 , Annalisa Contursi1 , Matteo Mucci1 , Lorenza Falcone1 , Elena Piazuelo2 , Carlos Sostres2 , Patrizia Ballerini1 , Angel Lanas2 , Paola Patrignani1 ( 1 Chieti, 2 Zaragoza - Spain)
O010
Validation of limited sampling strategy for estimating mycophenolic acid area under the curve in heart transplant recipients
Pier Giorgio Cojutti, Vincenzo Tursi, Sandro Sponga, Ugolino Livi, Federico Pea, Massimo Baraldo (Udine)
O011
A new platform for patient-based preclinical tests in muscular dystrophies: first steps towards an optogenetic engineered 3D artificial muscle
Ornella Cappellari, Francesca Sanarica2 , Dominic Wells3 , Annamaria De Luca2 ( 1 Manchester - United Kingdom, 2 Bari, 3 London - United Kingdom)
O012
Post-marketing safety of sacubitril/valsartan: emerging signals from the FDA Adverse Event Reporting System
Emanuel Raschi, Ippazio Cosimo Antonazzo, Elisabetta Poluzzi, Fabrizio De Ponti (Bologna)
O013
Molecular mechanisms underlying the association between hydrochlorothiazide use and the risk of non-melanoma skin cancers
Elisabetta Bigagli, Lorenzo Cinci, Mario D’Ambrosio, Astrid Parenti, Maura Lodovici, Alessandro Mugelli, Cristina Luceri (Florence)
O014
Computational tool for predicting drug-induced liver toxicity (DILT)
Simone Brogi, Valentina Citi, Vincenzo Calderone (Pisa)
O015
Direct-acting oral anticoagulants (DOACs) in pregnancy: new insight from VigiBase®
Maurizio Sessa1 , Annamaria Mascolo1 , Torbjörn Callréus1 , Annalisa Capuano1 , Francesco Rossi1 , Morten Andersen2 ( 1 Naples, 2 Copenhagen - Denmark)
O016
Italian emergency department visits and hospitalizations for outpatients’ adverse drug events: the MEREAFaPS Study
Niccolò Lombardi1 , Giada Crescioli1 , Alessandra Bettiol1 , Roberto Bonaiuti1 , Maria Parrilli1 , Martina Del Lungo1 , Linda Giovannetti1 , Valentina Borsi1 , Marco Rossi2 , Marco Tuccori3 , Annalisa Capuano4 , Alessandro Mugelli1 , Mauro Venegoni6 , Gi
O017
Pillars and pitfalls of the new pharmacovigilance legislation: consequences for the identification of adverse drug reactions deriving from abuse, misuse, overdose, occupational exposure, and medication errors
Gabriella di Mauro, Maurizio Sessa, Annamaria Mascolo, Angela Falco, Alessia Zinzi, Concetta Rafaniello, Liberata Sportiello, Cristina Scavone, Annalisa Capuano (Naples)
O018
Preventable cases of oral anticoagulant-induced bleeding: data from the spontaneous reporting system
Annamaria Mascolo, Rosanna Ruggiero, Maurizio Sessa, Cristina Scavone, Pasquale Maria Berrino, Liberata Sportiello, Concetta Rafaniello, Annalisa Capuano (Naples)
O019
Mandatory vaccination in Sicily: adverse events in children before and after the Law 119/2017
Anna Mecchio1 , Chiara Nasso1 , Michelangelo Rottura1 , Elisa Bongiorno1 , Paola Cutroneo1 , Giulia Maria Tarabini Castellani1 , Francesca Menniti Ippolito2 , Edoardo Spina1 , Domenica Altavilla1 ( 1 Messina, 2 Rome)
O020
Polypharmacy and drug-drug interactions at the time of admission to and discharge from a cardiac rehabilitation ward
Giuseppe Simeone, Chiara Resnati, Francesco Giallauria, Michele Arcopinto, Maddalena Illario, Antonello Cittadini, Mauro Cataldi (Naples)
O021
Antibiotic exposure and risk of Multiple Sclerosis: a population-based casecontrol study in the Emilia Romagna region
Ippazio Cosimo Antonazzo, Elisa Baldin, Corrado Zenesini, Luca Vignatelli, Emanuel Raschi, Roberto D’Alessandro, Elisabetta Poluzzi (Bologna)
O022
How much benefits and risks of new oral anticoagulants as observed in pivotal randomized clinical trials can be generalized to a real-world setting from Southern Italy?
Ylenia Ingrasciotta1 , Anna Mancuso1 , Andrea Fontana2 , Valentina Ientile1 , Maurizio Pastorello3 , Gianluca Trifirò1 ( 1 Messina, 2 San Giovanni Rotondo, 3 Palermo)
O023
Montelukast induces better control of symptoms and management of lung function, and decreased inflammation in women compared with men
Giuseppe Spaziano1 , Renata Esposito1 , Domenico Giannattasio2 , Francesco Ferrigno2 , Angela Liparulo1 , Antonietta Rossi1 , Fiorentina Roviezzo1 , Liberato Berrino1 , Mario Polverino2 , Francesca Polverino3 , Bruno D’Agostino1 ( 1 Naples, 2 Scafati, 3
O024
Efficacy and safety of pharmacological treatments for Patent Ductus Arteriosus closure: a systematic review and network meta-analysis of clinical trials and observational studies involving 15,725 subjects
Ettore Marconi1 , Alessandra Bettiol1 , Giuseppe Ambrosio2 , Vittorio Perduca3 , Alfredo Vannacci1 , Stefania Troiani2 , Carlo Dani1 , Alessandro Mugelli1 , Ersilia Lucenteforte4 ( 1 Florence, 2 Perugia, 3 Paris - France, 4 Pisa)
O025
Salivary Advanced Glycation end Products (AGEs) as novel biomarkers in evaluation of risk factors for diet-related diseases: results from the European Network SALIVAGES
Debora Collotta1 , Fausto Chiazza1 , Raffaella Mastrocola1 , Manuela Aragno1 , Chiara Cordero1 , Erica Liberto1 , Rosa M. Sáinz2 , Vanesa Cepas2 , Aranka Ileaa3 , Bianca A. Boscab3 , Jared Q. Gerlach4 , Marie Le Berre4 , Lokesh Joshi4 , Thomas Henle5 , F
O026
The NMDAR antagonist dextromethadone increases plasma BDNF levels in healthy volunteers: a phase 1 clinical study
Sara De Martin1 , Ottavio Vitolo2 , Galina Bernstein3 , Andrea Alimonti1 , Sergio Traversa2 , Charles Inturrisi2 , Paolo Manfredi2 ( 1 Padua, 2 New York - USA, 3 Toronto - Canada)
O027
Hsa-miR-34a-5p and hsa-miR-375 as biomarkers for monitoring the effects of drug treatment for migraine pain in children and adolescents: a pilot study
Luca Gallelli1 , Erika Cione2 , Francesco Peltrone1 , Serena Siviglia2 , Stefania Zampogna1 , Vincenzo Guidetti3 , Maria Cristina Caroleo2 , Giovambattista De Sarro1 ( 1 Catanzaro, 2 Cosenza, 3 Rome)
O028
Enteric alpha-synuclein inclusions, impaired intestinal permeability, enteric inflammation and colonic motor dysfunctions precede central neurodegeneration in a transgenic mouse model of Parkinson’s Disease
Carolina Pellegrini1 , Luca Antonioli1 , Rocchina Colucci2 , Laura Benvenuti1 , Vanessa D’Antongiovanni1 , Lucia Rota1 , Fabiana Miraglia1 , Giovanna Testa1 , Simona Capsoni1 , Antonino Cattaneo1 , Emanuela Colla1 , Corrado Blandizzi1 , Matteo Fornai1 (
O029
Cytokines IL-6, IL-8 and IL-33 as predictors of systemic inflammation in healthy smokers
Carmen Mannucci, Fabrizio Calapai, Emanuela Elisa Sorbara, Luigi Cardia, Sebastiano Gangemi, Gioacchino Calapai (Messina)
O030
E-cigarettes induce in vivo toxicological effects that can raise the cancer risk
Donatella Canistro1 , Fabio Vivarelli1 , Silvia Cirillo1 , Annamaria Buschini2 , Mirca Lazzaretti2 , Maria Teresa Rodriguez-Estrada1 , Maura Lodovici3 , Antonello Lorenzini1 , Silvia Marchionni1 , Paola Franchi1 , Marco Lucarini1 , Moreno Paolini1 ( 1 Bol
O031
Polymorphisms in dopaminergic receptor genes and multiple sclerosis progression
Marco Ferrari1 , Cristoforo Comi2 , Luca Magistrelli2 , Domizia Vecchio2 , Sandra D’Alfonso1 , Franca Marino1 , Marco Cosentino1 ( 1 Varese, 2 Novara)
O032
Gene editing of the intracellular immune checkpoint inhibitor AhR in cDC1 improves tumor regression
Marco Gargaro1 , Giulia Scalisi1 , Giorgia Manni1 , Dario Nardi1 , Paolo Puccetti1 , Kenneth M. Murphy2 , Francesca Fallarino1 ( 1 Perugia, 2 St. Louis - USA)
O033
Two retrospective studies on gender differences: chemotherapy toxicities in patients affected by colorectal and pancreatic cancers
Silvia De Francia, Paola Berchialla, Tiziana Armando, Silvia Racca, Sarah Allegra, Andrea Elio Sprio, Silvana Storto, Libero Ciuffreda, Maria Valentina Mussa (Turin)
O034
GPBAR1 functions as gatekeeper for liver NKT cells and provides counter regulatory signals in autoimmune hepatitis
Michele Biagioli1 , Adriana Carino1 , Chiara Fiorucci1 , Silvia Marchianò1 , Margherita Magro1 , Eleonora Distrutti2 , Oxana Bereshchenko3 , Paolo Scarpelli4 , Angela Zampella2 , Stefano Fiorucci1 ( 1 Perugia, 2 Naples)
O035
IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation
Federica Raucci1 , Asif J. Iqbal2 , Paola Minosi3 , Gian Marco Casillo1 , Anella Saviano1 , Marina Russo1 , Stefano Pieretti3 , Nicola Mascolo1 , Francesco Maione1 ( 1 Naples, 2 Birmingham - United Kingdom, 3 Rome)
O036
Leukocyte integrin antagonists as a novel option to treat dry age-related macular degeneration
Monica Baiula, Alberto Caligiana, Giulia Martelli, Daria Giacomini, Luca Gentilucci, Santi Spampinato (Bologna)
O037
The pharmacological inhibition of caspase-1- does not revert Particulate Matter (PM)-induced lung immunesuppression in mice
Chiara Colarusso1 , Michela Terlizzi1 , Fiorentina Roviezzo2 , Ida Cerqua2 , Giuseppe Cirino2 , Aldo Pinto1 , Rosalinda Sorrentino1 ( 1 Salerno, 2 Naples)
O038
Glucocorticoid-induced leucine zipper (GILZ) inhibits MAPK pathway activation thus limiting neutrophil activation
Simona Ronchetti, Erika Ricci, Elena Roselletti, Marco Gentili, Claudia Monari, Graziella Migliorati, Anna Vecchiarelli, Carlo Riccardi (Perugia)
O039
Communication between macrophages and cancer cells orchestrates lipid mediator biosynthesis
Simona Pace, Markus Werner, Anna Czapka, Paul Jordan, Fabiana Troisi, Jana Gerstmeier, Andreas Koeberle, Oliver Werz (Jena - Germany)
O040
Palmitoylethanolamide counteracts neurogenic inflammation in vitro by stimulating 2-arachidonoyl-glycerol biosynthesis and synergising with endocannabinoid signaling at the cannabinoid receptor type-2
Stefania Petrosino1 , Aniello Schiano Moriello1 , Roberta Verde1 , Marco Allarà1 , Roberta Imperatore1 , Alessia Ligresti1 , Ali Mokhtar Mahmoud1 , Alessio Filippo Peritore1 , Fabio Arturo Iannotti1 , Vincenzo Di Marzo1,2 ( 1 Pozzuoli, 2 Quebéc City - C
O041
Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1
Elisa Albini, Maria Teresa Pallotta, Giada Mondanelli, Marco Gargaro, Claudia Volpi, Ciriana Orabona (Perugia)
O042
Modulation of myeloid derived suppressor cells: a new strategy towards hydrogen sulfide anti-cancer effects
Paola De Cicco1 , Giuseppe Ercolano1 , Theodore Sanders2 , Kevin J Maloy2 , Valentina Rubino1 , Giuseppe Terrazzano1 , Giuseppina Ruggiero1 , Giuseppe Cirino1 , Angela Ianaro1 ( 1 Naples, 2 Oxford - United Kingdom)
O043
Hydrogen sulfide and pro-resolving pathway: a possible interplay in endothelial cells
Vincenzo Brancaleone1 , Valentina Vellecco2 , Rosangela Montanaro1 , Onorina Laura Manzo2 , Giuseppe Cirino2 ( 1 Potenza, 2 Naples)
O044
Platelet-specific deletion of cyclooxygenase-1 ameliorates dextran sulfate sodium-induced colitis in mice
Annalisa Bruno1 , Annalisa Contursi1 , Melania Dovizio1 , Stefania Tacconelli1 , Emanuela Ricciotti2 , Paloma Guillem-Llobat1 , Tania Salvatore1 , Luigia Di Francesco1 , Rosa Fullone1 , Patrizia Ballerini1 , Vincenzo Arena3 , Sara Alberti1 , Guizhu Liu4 ,
O045
Antinflammatory, antioxidant, and behavioural effects induced by MIA-690 and MR-409 administration in mice
Sheila Leone1 , Lucia Recinella1 , Annalisa Chiavaroli1 , Giustino Orlando1 , Claudio Ferrante1 , Guya Diletta Marconi1 , Iacopo Gesmundo2 , Riccarda Granata2 , Renzhi Cai3 , Whei Sha3 , Andrew V. Schally3 , Luigi Brunetti1 ( 1 Chieti, 2 Turin, 3 Miami -
O046
Innovative kappa opioid receptor agonists with different bias towards G proteindependent signaling: molecular pathway analysis and pharmacological effects
Andrea Bedini1 , Lorenzo Di Cesare Mannelli2 , Laura Micheli2 , Rossella De Marco1 , Luca Gentilucci1 , Carla Ghelardini2 , Santi Spampinato1 ( 1 Bologna, 2 Florence)
O048
Forced exercise induces anxiety-like behavior associated with reduced electrophysiological neuronal activity and gut and brain endocannabinoidome changes
Flavia Ricciardi, Maria Donniacuo, Serena Boccella, Monica Iannotta, Fabiana Piscitelli, Sabatino Maione, Vincenzo Di Marzo, Francesca Guida, Barbara Rinaldi (Naples)
O050
Effect of high-fat diet and Toll-like receptor 4 on the integrity of mouse enteric and central nervous systems
Ilaria Marsilio1 , Valentina Caputi1 , Silvia Cerantola1 , Michela Bistoletti2 , Cristina Giaroni2 , Morena Zusso1 , Maria Cecilia Giron1 ( 1 Padua, 2 Varese)
O051
Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug
Luigi Sironi1 , Elisabetta Bonfanti1 , Paolo Gelosa1 , Laura Castiglioni1 , José Maria Delgado-Garcia2 , Agnès Gruart2 , Lucia Fontana1 , Marco Gotti1 , Elena Tremoli1 , Davide Lecca1 , Marta Fumagalli1 , Mauro Cimino3 , Ludwig Aigner4 , Maria Pia Abbra
O052
O053
Satiety factor oleoylethanolamide prevents binge-like palatable food consumption induced by stress in female rats with a history of food restriction
Adele Romano1 , Maria Vittoria Micioni Di Bonaventura2 , Cristina Anna Gallelli1 , Justyna Barbara Koczwara1 , Maria Elena Giusepponi2 , Tommaso Cassano3 , Carlo Cifani2 , Silvana Gaetani1 ( 1 Rome, 2 Camerino, 3 Foggia)
O054
Role of NCX1 and NCX3 in neurodegeneration and neuroinflammation in the A53T transgenic mouse model of Parkinson’s Disease
Rossana Sirabella1 , Maria Josè Sisalli1 , Giulia Costa2 , Rossana Di Martino1 , Micaela Morelli2 , Gianfranco Maria Di Renzo1 , Lucio Annunziato1 , Antonella Scorziello1 ( 1 Naples, 2 Cagliari)
O055
Reverting the electrophysiological alterations caused by HCN loss of function to protect vulnerable dopaminergic neurons in MitoPark mouse model
Carmen Carbone1 , Daniela Iezzi1 , Alice Ilari2 , Guido Mannaioni1 , Alessio Masi2 ( 1 Florence, 2 Camerino)
O056
Purinergic current in microglia is enhanced by metabotropic glutamate receptor activation
Mariangela Chisari, Michele Barraco, Maria Angela Sortino (Catania)
O057
Cannabis sativa L. extract and cannabidiol exert anti-inflammatory effects in human fibroblasts and keratinocytes
Enrico Sangiovanni1 , Marco Fumagalli1 , Barbara Pacchetti2 , Stefano Piazza1 , Andrea Magnavacca1 , Saba Khalilpour1 , Gloria Melzi1 , Giulia Martinelli1 , Mario Dell’Agli1 ( 1 Milan, 2 Riazzino - Switzerland)
O058
In vitro biological activities of essential oils from three Succulent plants in drug resistant diseases
Monica Notarbartolo, Maurizio Sajeva, Pietro Zito, Rosa Alduina, Paola Poma, Manuela Labbozzetta (Palermo)
O059
Phytochemical and pharmaco-toxicological characterization on water hemp extracts
Claudio Ferrante, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Luigi Brunetti, Luigi Menghini, Giustino Orlando (Chieti)
O060
Glucomoringin, a glucosinolates extracted from Moringa oleifera seeds, induces antiproliferative effect in human neuroblastoma cells
Santa Cirmi, Nadia Ferlazzo, Laura Musumeci, Caterina Russo, Alessandro Maugeri, Giovanni Enrico Lombardo, Michele Navarra (Messina)
O061
In utero cannabis exposure increases sensitivity of midbrain dopamine system and induces sensorimotor gating alterations in male but not female rats
Francesco Traccis, Claudia Sagheddu, Pierluigi Saba, Valeria Serra, Gabriele Giua, Mauro Congiu, Silvia Fanni, Paola Devoto, Roberto Frau, Miriam Melis (Cagliari)
O062
Administration of naringenin ameliorates DSpastin loss of function phenotypes in Drosophila melanogaster
Barbara Napoli1 , Alison Salvador1 , Alessia Forgiarini1 , Chiara Vantaggiato2 , Elena Panzeri2 , Andrea Martinuzzi3 , Genny Orso1 ( 1 Padua, 2 Lecco, 3 Conegliano)
O063
A new nutraceutical formulation as promising agent against inflammatory bowel diseases: in vitro evaluation on Caco-2 transwell mode
Antonella Smeriglio, Marcella Denaro, Clara De Francesco, Domenico Trombetta (Messina)
O065
Extra-virgin olive oil polyphenols oleocanthal, oleacein and hydroxytyrosol decrease adipocyte inflammation
Beatrice Polini1 , Marika Massaro2 , Sara Carpi1 , Maria Digiacomo1 , Clementina Manera1 , Marco Macchia1 , Egeria Scoditti2 , Paola Nieri1 ( 1Pisa, 2 Lecce)
O066
Supplementing punicalagin protects human retinal pigment epithelium cells (ARPE-19) from ultraviolet radiation-induced oxidative damage
Giuseppe Tringali, Beatrice Sampaolese, Francesca Sciandra, Maria Elisabetta Clementi (Rome)
O067
Bergamot polyphenols improve dyslipidemia and pathophysiological features in a mouse model of non-alcoholic fatty liver disease
Federica Scarano1 , Vincenzo Musolino1 , Micaela Gliozzi1 , Francesca Bosco1 , Miriam Scicchitano1 , Saverio Nucera1 , Cristina Carresi1 , Jessica Maiuolo1 , Stefano Ruga1 , Maria Caterina Zito1 , Roberta Macrì1 , Francesca Noto1 , Lorenza Guarnieri1 , R
O068
Protective effects induced by MOMAST(®) HY100 and MOMAST(®) HP30 in rat isolated tissues challenged with LPS
Annalisa Chiavaroli, Lucia Recinella, Giustino Orlando, Luigi Menghini, Claudio Ferrante, Luigi Brunetti, Sheila Leone (Chieti)
O069
In vitro cisplatin cytotoxicity in the testicular germ tumor cell line ntera-2 is enhanced by the CDK4/6 inhibitor palbociclib
Elisa Rossini, Valentina Bosatta, Andrea Abate, Martina Fragni, Alfredo Berruti, Maurizio Memo, Sandra Sigala (Brescia)
O070
miR-193a as new potential therapeutic agent and biomarker in cutaneous melanoma
Sara Carpi1 , Beatrice Polini1 , Leena Ylösmäki2 , Erkko Ylösmäki2 , Vincenzo Cerullo2 , Antonella Romanini1 , Paola Nieri1 ( 1 Pisa, 2 Helsinki - Finland)
O071
NAAA is crucially involved in proliferation, migration and in vivo colon tumorigenesis
Ester Pagano1 , Barbara Romano1 , Tommaso Venneri1 , Giovanna Vanacore1 , Fabio A. Iannotti1 , Alexandros Makriyannis2 , Micheal S. Malamas2 , Maria D’Armiento1 , Vincenzo Brancaleone3 , Fabiana Piscitelli1 , Vincenzo Di Marzo4 , Angelo A. Izzo1 , Franc
O072
Nicotinamide phosphoribosyltransferase (NAMPT) translocates to the nucleus following glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interaction and confers DNA damage resistance to melanoma cells
Ambra Grolla1 , Riccardo Miggiano1 , Daniele Di Marino2 , Michele Bianchi1 , Federica Gaudino3 , Giuseppe Orsomando4 , Ubaldina Galli1 , Silvia Garavaglia1 , Armando Genazzani1 ( 1 Novara, 2 Lugano - Switzerland, 3 Turin, 4 Ancona)
O073
Boosting the efficacy of doxorubicin against ovarian cancer by ultrasound stimulation
Federica Foglietta, Manuela Macrì, Roberto Canaparo, Arianna Marucco, Ivana Fenoglio, Patrizia Panzanelli, Giovanni Durando, Giampiero Muccioli, Enzo Terreno, Loredana Serpe (Turin)
O074
Role of the tumor cells and microenvironment in pancreatic tumor progression by detection of biomarkers in extracellular vesicles
Benedetta Ferrara1 , Damien Habert1 , Matteo Ponzo1 , Claire Houppel1 , Alba Nicolas-Boluda2 , Florence Gazean2 , Ilaria Cascone1 , Jose Courty1 , Anais Debesset1 , Fabio Raineri1 ( 1 Creteil - France, 2 Paris - France)
O075
Hemidesmus indicus induces immunogenic cell death in human colorectal cancer cells
Elena Catanzaro1 , Eleonora Turrini1 , Manuele Giuseppe Muraro2 , Emanuele Trella2 , Valeria Governa2 , Valentina Mele2 , Carmela Fimognari1 ( 1 Rimini, 2 Basel - Switzerland)
O076
PNN and KCNQ1OT1 are predictive biomarkers of clinical outcome in colorectal cancer patients treated with adjuvant fluoropyrimidine-based chemotherapy: a validation study
Stefania Nobili1 , Gabriele Perrone1 , Andrea Lapucci1 , Cristina Napoli1 , Ida Landini1 , Giandomenico Roviello1 , Laura Calosi1 , Antonio Giuseppe Naccarato2 , Alfredo Falcone2 , Daniele Bani1 , Antonello Di Paolo2 , Enrico Mini1 ( 1 Florence, 2 Pisa)
O077
“All roads lead to Rome
Gabriele Pizzino, Elena Grassi, Gianvito Urgese, Marilisa Montemurro, Andrea Bertotti (Turin)
O078
Circulating tumor DNA sequencing coupled with therapeutic drug monitoring as an innovative strategy for the pharmacological monitoring of GIST patients - A case report
Chiara Dalle Fratte, Rachele Borsatti, Elena De Mattia, Maurizio Polano, Mauro Buzzo, Sara Gagno, Bianca Posocco, Angela Buonadonna, Michela Guardascione, Giuseppe Toffoli, Erika Cecchin (Aviano)
O079
Effects of nanoparticles loaded with the epigenetic drug JQ1 against triple negative breast cancer cells
Valentina Maggisano, Marilena Celano, Stefania Bulotta, Donato Cosco, Massimo Fresta, Diego Russo (Catanzaro)
O080
Towards the identification of the mechanism of action of antitumor 1-methyl-Dtryptophan
Maria Teresa Pallotta, Alberta Iacono, Ciriana Orabona, Maria Laura Belladonna, Elisa Albini, Ursula Grohmann (Perugia)
O081
Metabotropic glutamate receptor type 5 as a target to reduce the reactive phenotype of spinal cord astrocytes from the SOD1G93A mouse model of amyotrophic lateral sclerosis
Tiziana Bonifacino, Marco Milanese, Carola Torazza, Francesca Provenzano, Elena Gallia, Silvia Ravera, Cesare Usai, Giambattista Bonanno (Genoa)
O082
Maintenance of Ca2+ homeostasis as strategy to prevent motor neuron degeneration
Serenella Anzilotti, Valeria Valsecchi, Ornella Cuomo, Agnese Secondo, Tiziana Petroziello, Natascia Guida, Lucio Annunziato, Giuseppe Pignataro (Naples)
O083
The GPR17 receptor as a new potential pharmacological target to restore oligodendroglial dysfunction in amyotrophic lateral sclerosis
Stefano Raffaele1 , Elisabetta Bonfanti1 , Tiziana Bonifacino2 , Marco Milanese2 , Erica Morgante1 , Giambattista Bonanno2 , Maria Pia Abbracchio1 , Marta Fumagalli1 ( 1 Milan, 2 Genoa)
O084
Evaluating the involvement of skeletal muscle ion channels in new rodent models of Amyotrophic Lateral Sclerosis to identify innovative therapeutic approaches
Nancy Tarantino1 , Giulia Maria Camerino1 , Elena Conte1 , Michela De Bellis1 , Adriano Fonzino1 , Gabriella Dobrowolny2 , Antonio Musarò2 , Annamaria De Luca1 , Sabata Pierno1 ( 1 Bari, 2 Rome)
O085
Repurposing metformin in Duchenne muscular dystrophy: a long-term preclinical evaluation in the dystrophic mdx mouse model
Paola Mantuano1 , Francesca Sanarica1 , Elena Conte1 , Maria Grazia Morgese2 , Roberta Francesca Capogrosso1 , Anna Cozzoli1 , Adriano Fonzino1 , Angelo Quaranta1 , Jean Francois Rolland3 , Michela De Bellis1 , Giulia Maria Camerino1 , Luigia Trabace1 , A
O086
Tubular aggregate myopathy caused by Orai1 and STIM1 mutations: a functional study in myoblast and myotubes of affected patients toward the identification of new therapeutic targets
Elena Conte1 , Giulia Maria Camerino1 , Alessandra Pannunzio1 , Dalila Sahbani1 , Concetta Altamura1 , Marina Mora2 , Lorenzo Maggi2 , Ornella Cappellari1 , Annamaria De Luca1 , Mauro Coluccia1 , Paola Imbrici1 , Antonella Liantonio1 ( 1 Bari, 2 Milan)
O087
Characterization of a tubular aggregate myopathy mouse model
Celia Cordero Sanchez1 , Beatrice Riva1 , Simone Reano1 , Alessandra Bertoni1 , Matteo Garibaldi2 , Cristina Travelli1 , Federico Alessandro Ruffinatti1 , Nicoletta Filigheddu1 , Armando A. Genazzani1 ( 1 Novara, 2 Rome)
O088
Study of novel modulators of store-operated calcium entry as a therapy for tubular aggregate myopathy
Beatrice Riva1 , Celia Cordero Sanchez1 , Simone Reano1 , Matteo Garibaldi2 , Tracey Pirali1 , Marta Serafini1 , Rosanna Di Paola3 , Nicoletta Filigheddu1 , Armando A. Genazzani1 ( 1 Novara, 2 Rome, 3 Messina)
O089
Anomalous Kv7 potassium channel activity in human Malignant Hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle
Valentina Vellecco1 , Alma Martelli2 , Iris Sofia Bibli3 , Onorina Laura Manzo1 , Elisabetta Panza1 , Valentina Citi2 , Vincenzo Calderone2 , Gianfranco de Dominicis1 , Caterina Cozzolino1 , Marianna Vallifuoco1 , Elisabetta Maria Basso1 , Martina Marinie
O091
Analytical and biochemical analysis of trans-sulfuration pathway-related genes, proteins and metabolites in skeletal muscles of MDX mice, a murine model of Duchenne’s muscle dystrophy
Elisabetta Panza1 , Valentina Vellecco1 , Fabio Arturo Iannotti2 , Onorina Laura Manzo1 , Deborah Paris2 , Giuseppe Cirino1 , Mariarosaria Bucci1 ( 1 Naples, 2 Pozzuoli)
O092
An overview of the safety of deferiprone in paediatric patients with congenital haemoglobinopathies and chronic iron overload
Adriana Ceci1 , Rosa Conte1 , Antonella Didio1 , Donato Bonifazi1 , Mariagrazia Felisi2 , Viviana Giannuzzi1 , Fedele Bonifazi1 ( 1 Bari, 2 Pavia)
O094
Antidepressants and cerebral energy metabolism: new functional proteomic insights
Federica Ferrari1 , Fabio Tascedda2 , Nicoletta Brunello2 , Roberto Federico Villa1 ( 1 Pavia, 2 Modena)
O095
Stress-induced modulation of the oxidative balance in the rat brain: effect of the antipsychotic lurasidone
Maria Serena Paladini1 , Andrea Carlo Rossetti1 , Vittoria Spero1 , Paola Brivio1 , Mariusz Papp2 , Francesca Calabrese1 , Marco Andrea Riva1 , Raffaella Molteni1 ( 1 Milan, 2 Kracow - Poland)
O096
The role of N-acetilcysteine in major psychiatric disorders
Beatrice Benatti, Vera De Carlo, Federica Giorgetti, Benedetta Grancini, Caterina Viganò, Bernardo Dell’Osso (Milan)
O097
Impact of NADPH oxidase inhibition on ketamine-induced dysfunctions: preclinical findings
Stefania Schiavone, Maria Grazia Morgese, Stefania Dimonte, Paolo Tucci, Luigia Trabace (Foggia)
O098
Neuropsychiatric clinical manifestations in elderly patients treated with hydroxychloroquine: a review article
Anna Larato1 , Annamaria Mascolo1 , Pasquale Maria Berrino1 , Pietro Gareri2 , Alberto Castagna2 , Annalisa Capuano1 , Ciro Manzo1 , Liberato Berrino1 ( 1 Naples, 2 Catanzaro)
O099
Oxytocin/dopamine receptor bivalent ligands: a new strategy to treat neuropsychiatric and neurodevelopmental disorders
Marta Busnelli, Arianna Costanzo, Francesca Santini, Alessandro Gori, Bice Chini (Milan)
O100
Investigating the molecular mechanisms of trazodone antidepressant activity: impact on trophic factors and circadian rhythm genes
Lucia Carboni, Francesca F. Caputi, Laura Rullo, Serena Stamatakos, Sanzio Candeletti, Patrizia Romualdi (Bologna)
O101
A single exposure to cocaine during adolescence segregates anhedonic and resilient rats: the role of the neurotrophin BDNF
Francesca Mottarlini, Francesca Telese, Giorgia Bottan, Lucia Caffino, Fabio Fumagalli (Milan)
O102
Potential effects of a novel formyl peptide receptor 2 agonist in two mouse models of autism spectrum disorder
Claudia Cristiano1 , Enza Lacivita2 , Floriana Volpicelli1 , Roberto Russo1 , Carla Perrone Capano1 , Marcello Leopoldo2 , Antonio Calignano1 ( 1 Naples, 2 Bari)
O103
Electrophysiological investigation of the reward system in the valproic acid model of autism
Daniela Iezzi1 , Carmen Carbone1 , Alice Ilari2 , Michele Petrella2 , Guido Mannaioni1 , Alessio Masi2 ( 1 Florence, 2 Camerino)
O104
Depression and brain fog “clearing up
Adriano Lama1 , Claudio Pirozzi1 , Chiara Annunziata1 , Maria Grazia Morgese2 , Claudia Cristiano1 , Luigia Trabace2 , Antonio Calignano1 , Rosaria Meli1 , Giuseppina Mattace Raso1 ( 1 Naples, 2 Foggia)
O105
Chronic inhibition of fatty acid amide hydrolase. The Alzheimer-like phenotype in 3×TG-AD mice
Tommaso Cassano1 , Silvio Calcagnini2 , Gaurav Bedse2 , Michele Lavecchia2 , Alessandra Caruso2 , Sergio Scaccianoce2 , Marialuisa de Ceglia2 , Cristina Anna Gallelli2 , Marzia Friuli2 , Adele Romano2 , Silvana Gaetani2 (1 Foggia, 2 Rome)
O106
The kynurenine pathway as potential target for neuroprotection
Sarah Beggiato, Maria Cristina Tomasini, Sofia Marina Simioni, Stefano Guerzoni, Luca Ferraro (Ferrara)
O107
Neuroprotective effects of celecoxib against β-amyloid-induced damage through the regulation of heme oxygenase-1 in SH-SY5Y cells
Emanuela Mhillaj1 , Vincenzo Cuomo1 , Luigia Trabace2 , Cesare Mancuso1 ( 1 Rome, 2 Foggia)
O108
Potential targets for neuroprotective agents in Huntington’s Disease
Letizia Pruccoli1 , Gabriella Teti2 , Mirella Falconi2 , Andrea Tarozzi1 ( 1 Rimini, 2 Bologna)
O109
Novel curcumin analogues as inhibitors of microglia pro-inflammatory activation in response to amyloid-beta oligomers
Morena Zusso1 , Gloria Galli1 , Lara Luise1 , Jessica Battaglia1 , Federica Bisceglia2 , Federica Belluti3 , Ersilia De Lorenzi2 , Pietro Giusti1 ( 1 Padua, 2 Pavia, 3 Bologna)
O110
Carnosine prevents Aβ-induced oxidative stress and inflammation in microglial cells: a key role of TGF-β1
Giuseppe Caruso1 , Claudia Giuseppina Fresta2 , Nicolò Musso3 , Mariaconcetta Giambirtone1 , Margherita Grasso1 , Simona Federica Spampinato3 , Sara Merlo3 , Filippo Drago3 , Giuseppe Lazzarino3 , Maria Angela Sortino3 , Susan Marie Lunte2 , Filippo Cara
O111
Melatonin via SIRT1 activation attenuates microglial neurotoxic effects during hypoxia
Sara Merlo, Simona Federica Spampinato, Grazia Ilaria Caruso, Maria Angela Sortino (Catania)
O112
PQM130, a novel feruloyl-donepezil hybrid compound, exerts neuroprotective effects and ameliorates memory impairments in a mouse model of Alzheimer’s Disease
Fabiana Morroni1 , Giulia Sita1 , Agnese Graziosi1 , Letizia Pruccoli2 , Andrea Tarozzi2 , Patrizia Hrelia1 ( 1 Bologna, 2 Rimini)
O113
Characterization of a mouse model of primary progressive multiple sclerosis and effects of neuroprotective strategies on disease evolution
Daniela Buonvicino, Giuseppe Ranieri, Sara Pratesi, Daniele Guasti, Alberto Chiarugi (Florence)
O114
The cyclase-associated protein 2 is a novel regulator of cofilin in synaptic plasticity and Alzheimer’s Disease
Elena Marcello1 , Silvia Pelucchi1,2, Lina Vandermeulen1 , Lara Pizzamiglio1 , Bahar Aksan3 , Jing Yan3 , Anja Konietzny4 , Elisa Bonomi5 , Barbara Borroni5 , Marco Rust6 , Daniele Di Marino7 , Marina Mikhaylova4 , Daniela Mauceri3 , Flavia Antonucci1 , F
O115
Neuroprotective effect of sodium propionate in neuroinflammation models
Marika Lanza, Alessia Filippone, Michela Campolo, Giovanna Casili, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito (Messina)
O116
Neuroprotective effect of dimethylfumarate on oxaliplatin-Induced neuropathic pain
Michela Campolo, Giovanna Casili, Irene Paterniti, Alessia Filippone, Marika Lanza, Salvatore Cuzzocrea, Emanuela Esposito (Messina)
O117
Preventing immediate and long-term adolescent stress-induced cognitive deficits and gut microbiota alterations by Omega-3 polyunsaturated fatty acids/ Vitamin A diet enrichment
Gustavo Provensi1 , Scheila Daiane Schmidt2 , Marcus Boehme3 , Barbara Rani1 , Alessia Costa1 , Patrizio Blandina1 , Ivan Izquierdo2 , John F. Cryan3 , Maria Beatrice Passani1 ( 1 Florence, 2 Porto Alegre - Brazil, 3 Cork - Ireland)
O118
Implication of undigested gluten peptides on neurological disorders: study of molecular mechanisms in experimental models of epileps
Elisabetta Gerace, Francesco Resta, Elisa Landucci, Daniela Renzi, Alessio Masi, Domenico E. Pellegrini-Giampietro, Antonio Calabrò, Guido Mannaioni (Florence)
O119
The glutamate synapse in an animal model of anorexia nervosa
Giorgia Bottan, Francesca Mottarlini, Giorgia Targa, Francesca Telese, Fabio Fumagalli, Lucia Caffino (Milan)
O120
3-iodothyroacetic acid is endowed of antidepressant effect depending on brain histamine release
Annunziatina Laurino, Manuela Gencarelli, Elisa Landucci, Lorenzo Cinci, Laura Raimondi (Florence)
O121
O122
Pleiotropic agents against Alzheimer’s Disease: in vitro toxicological screening on recently developed SG-compounds
Massimiliano Runfola1 , Simona Sestito1 , Grazia Chiellini1 , Sheraz Gul2 , Simona Rapposelli1 ( 1 Pisa, 2 Hamburg - Germany)
O123
Brown adipogenic reprogramming by palmitoylethanolamide in high fat dietinduced obese mice
Chiara Annunziata1 , Martina Senzacqua2 , Adriano Lama1 , Claudio Pirozzi1 , Maria Pina Mollica1 , Giuseppina Mattace Raso1 , Saverio Cinti2 , Antonio Giordano2 , Rosaria Meli1 ( 1 Naples, 2 Ancona)
O124
Role of exogenous dietary advanced glycation end products (AGEs) in the cross-talk mechanisms linking diet, microbiota and metabolic inflammation
Debora Collotta1 , Alessia Sofia Cento1 , Fausto Chiazza1 , Roberta Verta1 , Thomas Henle2 , Friederike Manig2 , Michael Hellwig2 , Giulia Gaudioso3 , Francesca Fava3 , Kieran Tuohy3 , Manuela Aragno1 , Raffaella Mastrocola1 , Massimo Collino1 ( 1 Turin,
O125
Effects of metformin and aerobic exercise training on the skeletal muscle of a murine model
Eleonora Maniscalco1 , Giuliana Abbadessa1 , Loredana Grasso1 , Paolo Borrione2 , Silvia Racca1 ( 1 Turin, 2 Rome)
O126
Genistein protects primary murine osteoblasts from oxidative stress in an in vitro experimental model
Federica Mannino, Natasha Irrera, Giovanni Pallio, Domenica Altavilla, Francesco Squadrito, Alessandra Bitto (Messina)
O127
Effects of MIA-690 administration on feeding, locomotor activity and hypothalamic neuromodulators in mice
Lucia Recinella1 , Sheila Leone1 , Annalisa Chiavaroli1 , Giustino Orlando1 , Claudio Ferrante1 , Iacopo Gesmundo2 , Riccarda Granata2 , Renzhi Cai3 , Whei Sha3 , Andrew V. Schally3 ( 1 Chieti, 2 Turin, 3 Miami - USA)
O128
Cyanidin-3-O-glucoside ameliorates palmitate-induced in ammation and insulin resistance in murine adipocytes
Antonio Speciale, Maria So a Molonia, Claudia Muscarà, Cristina Occhiuto, Romina Bashllari, Antonella Saija, Francesco Cimino (Messina)
O129
Do P2Y12 receptor antagonism and NLRP3 inhibition exert additive cardioprotective effects against ischemia/reperfusion injury?
Fausto Chiazza, Saveria Femminò, Debora Collotta, Elisa Zicola, Manuela Aragno, Massimo Bertinaria, Pasquale Pagliaro, Claudia Penna, Massimo Collino (Turin)
O130
The mGlu5 negative allosteric modulator MPEP protects against cold ischemic injury in rat livers from donor after cardiac death
Roberta Verta1 , Clarissa Berardo2 , Veronica Siciliano2 , Laura G. Di Pasqua2 , Debora Collotta1 , Ferdinando Nicoletti3 , Mariapia Vairetti2 , Massimo Collino1 , Andrea Ferrigno2 ( 1 Turin, 2 Pavia, 3 Rome)
O131
Early and transient activation of MAPKs and matrix metalloproteinases contributes to hepatic ischemia/reperfusion injury
Laura G. Di Pasqua1 , Giuseppina Palladini1 , Clarissa Berardo1 , Roberta Verta2 , Veronica Siciliano1 , Plinio Richelmi1 , Debora Collotta2 , Massimo Collino2 , Mariapia Vairetti1 , Andrea Ferrigno1 ( 1 Pavia, 2 Turin)
O132
Proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency is associated with altered glucose metabolism, pancreatic function and insulin release
Lorenzo Da Dalt, Carla Perego, Alessandra Galli, Alberico Luigi Catapano, Giuseppe Danilo Norata (Milan)
O134
Cardioprotective properties of a promising isothiocyanate: from the H2 Sreleasing properties to the in vivo cardioprotective effects
Valentina Citi1 , Simone Brogi1 , Lorenzo Flori1 , Era Gorica1 , Eugenia Piragine1 , Beatrice Severino2 , Angela Corvino2 , Alma Martelli1 , Lara Testai1 , Giuseppe Caliendo2 , Vincenzo Calderone1 ( 1 Pisa, 2 Naples)
O135
Vascular effects of Erucin, a H2 S-donor from Eruca sativa Mill., against oxidative and pro-inflammatory stimuli
Alma Martelli1 , Eugenia Piragine1 , Valentina Citi1 , Lara Testai1 , Roberto Matteo2 , Luisa Ugolini2 , Eleonora Pagnotta2 , Luca Lazzeri2 , Lorenzo Di Cesare Mannelli3 , Valentina Vellecco4 , Vincenzo Brancaleone5 , Mariarosaria Bucci4 , Carla Ghelardin
O136
Hydrogen sulfide is responsible for the cardioprotective effects of the isothiocyanate erucin in an experimental model of acute myocardial infarct
Lara Testai1 , Lorenzo Flori1 , Valentina Citi1 , Eugenia Piragine1 , Vincenzo Brancaleone2 , Era Gorica1 , Eleonora Pagnotta3 , Lorenzo Di Cesare Mannelli4 , Alma Martelli1 , Luisa Ugolini3 , Luca Lazzeri3 , Carla Ghelardini4 , Vincenzo Calderone1 ( 1 Pi
O137
Engineered regulatory T cell adoptive therapy as a novel tool for the treatment of atherosclerosis
Fabrizia Bonacina1 , Elisa Martini2 , Marco Cremonesi2 , Annalisa Moregola1 , Stefano Garetto2 , Alberico Luigi Catapano1 , Fabio Pellegatta3 , Marinos Kallikourdis2 , Giuseppe Danilo Norata1 ( 1 Milan, 2 Rozzano, 3 Cinisello Balsamo)
O138
MicroRNA-34a inhibition in rats with doxorubicin-induced cardiotoxicity
Elena Piegari, Anna Cozzolino, Loreta Pia Ciuffreda, Donato Cappetta, Antonella De Angelis, Konrad Urbanek, Maria Saturno, Liberato Berrino (Naples)
O139
Mitochondrial dynamics unbalance in a model of cardiac hypertrophy: effect of fenofibrate treatment
Laura Castiglioni, Marco Gotti, Giuseppe Busca, Elena Tremoli, Paolo Gelosa, Luigi Sironi (Milan)
O140
Effects of sacubitril/valsartan on diastolic function in aging rats
Donato Cappetta, Konrad Urbanek, Elena Piegari, Loreta Pia Ciuffreda, Anna Cozzolino, Agostino Miccichè, Stefania Sicuranza, Francesco Rossi, Antonella De Angelis, Liberato Berrino (Naples)
O141
An overview of the safety of deferiprone in pediatric patients with congenital haemoglobinopathies and chronic iron overload
Adriana Ceci1, Rosa Conte1, Antonella Didio1, Donato Bonifazi1, Mariagrazia Felisi2, Viviana Giannuzzi1, Fedele Bonifazi1 (1Bari, 2Pavia)
O142
Poster
Neuroadaptive changes in the reward system in an animal model of voluntary ethanol consumption
Alice Ilari1 , Daniela Iezzi2 , Michele Petrella1 , Guido Mannaioni2 , Roberto Ciccocioppo1 , Alessio Masi1 ( 1 Camerino, 2 Florence)
P001
4-methylpyrazole injection into the pVTA is able to prevent ethanol selfadministration behavior in rats
Paola Arrigo, Andrea Bacciu, Alessandra Tiziana Peana, Gaia Rocchitta, Pier Andrea Serra (Sassari)
P002
Real-time biosensing of glucose, lactate and glutamate extracellular levels in Nucleus Accumbens of freely moving rats after systemic ethanol administration
Gaia Rocchitta, Paola Arrigo, Andrea Bacciu, Patrizia Monti, Alessandra Tiziana Peana, Pier Andrea Serra (Sassari)
P003
Opioid abuse vulnerability in genetically selected Marchigian sardinian alcoholpreferring rat
Federica Benvenuti, Veronica Lunerti, Hong-Wu Li, Giada Pacinelli,Nazzareno Cannella, Roberto Ciccocioppo (Camerino)
P004
Modelling the individual variability to develop heroin dependence in outbred NIH heterogeneous stock rats
Veronica Lunerti1, Giulia Scuppa2, Stefano Tambalo2, Linda Marcotulli1, FabioCasarola1, Alessio Masi1, Massimo Ubaldi1, Carlo Lucheroni1, Angelo Bifone2Roberto Ciccocioppo1, Nazzareno Cannella1 (Camerino, 2Rovereto)
P005
Effects of cocaine self-administration on the glutamate synapse in theinfralimbic region of the medial prefrontal cortex: the role of serotonin
Francesca Telese1, Francesca Mottarlini1, Lucia Caffino1, Boyd vanReijmersdal2, Michel Verheji2, Judith Homberg2, Fabio Fumagalli1 (Milan, 2Nijmegen - The Netherlands)
P006
Dysregulation of BDNF signaling in the amygdala of rats lacking the serotonintransporter following long-access cocaine self-administration
Francesca Mottarlini1, Lucia Caffino1, Michel Verheji2, Judith Homberg2Fabio Fumagalli1 (Milan, 2Nijmegen - The Netherlands)
P007
Role of nucleus accumbens subregions in incubation of methamphetaminecraving after voluntary abstinence
Ludovica Maddalena Rossi1, Ingrid Reverte1, Davide Ragozzino1, AldoBadiani1, Marco Venniro2, Daniele Caprioli1 (Rome, 2Baltimore - USA)
P008
Short- and long-term nicotine withdrawal effects on behaviour and rewarding properties of methylene-dioxymethamphetamine (MDMA) in zebrafish
Luisa Ponzoni1, Daniela Braida1, Milena Moretti1, Jose V. Torres-Pérez2 Caroline Brennan2, Cecilia Gotti1, Mariaelvina Sala1 (Milan, 2London - United Kingdom)
P010
Alpha-synuclein/synapsin III interplay orchestrates the locomotor response to psychostimulants such as cocaine and methylphenidate
Gaia Faustini1, Francesca Longhena1, Maria Grazia Spillantini2, Marina Pizzi1, Arianna Bellucci1(1Brescia, 2Cambridge - United Kingdom)
P011
Effect of N-acylethanolamine acid amidase inhibition on mesolimbic dopamine and locus coeruleus noradrenergic neuronal responses to morphine
Michele Santoni1, Mauro Congiu1, Claudia Sagheddu1, AlexandrosMakriyannis2, Michael Malamas2, Marco Pistis1 (Cagliari, 2Boston - USA)
P012
Remembering to forget: the role of brain carbonic anhydrases on fear memory extinction
Scheila Daiane Schmidt1, Barbara Rani2, Alessia Costa2, Fabrizio Carta2,Jociane de Carvalho Myskiw1, Maria Beatrice Passani2, Ivan Izquierdo1Claudiu Trandafir Supuran2, Patrizio Blandina2, Gustavo Provensi2 (PortoAlegre - Brazil, 2Florence)
P013
Inside the multimodal effects of maternal separation in C57BL6J mice:early life stress and changes in neuronal functions, cognitive and motivated behaviors
Giuseppe Talani, Eleonora Saolini, Daniele Colombo, Gian Marco Calandra,Francesca Biggio, Giovanni Biggio, Enrico Sanna (Cagliari)
P014
Long-term impact of prenatal stress exposure on acute responsiveness in adult mice: focus on inflammation and oxidative balance
Vittoria Spero, Maria Serena Paladini, Francesco Picotti, Eleonora Buscemi,Andrea C. Rossetti, Raffaella Molteni (Milan)
P015
Stress regulates glucocorticoid-responsive genes expression in prefrontal cortex by altering DNA methylation: implication for lurasidone treatment
Paola Brivio1, Giulia Sbrini1, Letizia Tarantini1, Chiara Favero1, Mariusz Papp2, Marco Andrea Riva1, Valentina Bollati1, Francesca Calabrese1 (1Milan, 2Cracovia - Poland)
P016
Modulation of the nop receptor signaling affects stress coping responses inmice: implications for resilience to stress
Joaquim Azevedo Neto1, Victor Anastacio Duarte Holanda2, SalvatorePacifico1, Luca Finetti1, Girolamo Calò1, Elaine Cristina Gavioli2, ChiaraRuzza1 (1Ferrara, 2Natal - Brazil)
P017
Omega3 PUFA/Vitamin A enriched diet confers resilience to stress-induced cognitive and neurophysiological modifications. Role of the brain histaminergic system
Alessia Costa1, Barbara Rani2, Francesco Bonfiglio2, Scheila Daiane Schmidt3, Gustavo Provensi2, Patrizio Blandina2, Renato Corradetti2, Maria Beatrice Passani2 (Manchester - United Kingdom, 2Florence, 3Porto Alegre - Brazil)
P018
Depression and anxiety as obesity-related comorbidities: possible protective effects of acylethanolamides
Marzia Friuli1, Adele Romano1, Maria Vittoria Micioni Di Bonaventura2, MariaElena Giusepponi2, Marialuisa de Ceglia1, Cristina Anna Gallelli1, JustynaBarbara Koczwara1, Emanuela Micioni Di Bonaventura2, Tommaso Cassano3,Carlo Cifani2, Silvana Gaetani1 (1R
P019
Effects of oleoylethanolamide on the brain circumventricular organs: novel insights on OEA anti-obesity effects
Adele Romano1 , Marzia Friuli1 , Marialuisa de Ceglia1, Cristina Anna Gallelli1,Justyna Barbara Koczwara1, Maria Vittoria Micioni di Bonaventura2, Carlo Cifani2, Giulio Muccioli3, Silvana Gaetani1 (1Rome, 2Camerino, 3Brussels -Belgium)
P020
Dysregulation of structural plasticity in an experimental model of anorexia nervosa: focus on the medial prefrontal cortex
Giorgia Bottan, Francesca Mottarlini, Francesca Telese, Benedetta Tarenzi,Fabio Fumagalli, Lucia Caffino (Milan)
P021
Health consequences of bulimia nervosa
Walter Milano1, Anna Capasso2 (1Naples, 2Salerno)1Naples, 2Salerno)
P023
Effect on binge eating episode in female rats of a potent σ1 antagonist analogue of spipethiane
Emanuela Micioni Di Bonaventura, Fabio Del Bello, Maria Vittoria Micioni Di Bonaventura, Gianfabio Giorgioni, Wilma Quaglia, Alessandro Piergentili,Carlo Cifani (Camerino)
P024
Fluoxetine and vortioxetine reverse depressive-like phenotype and memory deficits induced by amyloid-β(1-42) oligomers in mice: a key role of Transforming Growth Factor-β1
Sebastiano Alfio Torrisi1, Federica Geraci1, Margherita Grasso2, MariaRosaria Tropea1, Giuseppe Caruso2, Annamaria Fidilio1, Nicolò Musso1,Giulia Sanfilippo1, Fabio Tascedda3, Agostino Palmeri1, Salvatore Salomone1,Filippo Drago1, Daniela Puzzo1, Gian Ma
P025
Effect of melanocortins in a transgenic mouse model of severe Alzheimer’s Disease
Eleonora Vandini, Antonietta Vilella, Eleonora Daini, Letizia Manca,Alessandra Ottani, Michele Zoli, Salvatore Guarini, Daniela Giuliani, Carlo Baraldi, Anita Calevro (Modena)
P026
Esculetin protects against mutant huntingtin-induced toxicity in Huntington’s Disease models
Letizia Pruccoli1, Carlo Breda2, Flaviano Giorgini2, Gabriella Teti3, MirellaFalconi3, Andrea Tarozzi1 (1Rimini, 2Leicester - United Kingdom, 3Bologna)
P027
A drug repurposing strategy for identifying novel pharmacological targets in a murine model of Down syndrome
Maria Elisa Salvalai, Valeria Bortolotto, Er Xia, Pier Luigi Canonico,Mariagrazia Grilli(Novara)
P028
A new neuroprotective role for dimethyl fumarate in experimental multiple sclerosis: inhibition of miR-142-3p to prevent inflammation-driven synaptic toxicity
Alessandra Musella1, Francesca De Vito2, Diego Fresegna1, Antonietta Gentile1, Silvia Bullitta1, Francesca Romana Rizzo1, Valentina Vanni1, LiviaGuadalupi1, Ettore Dolcetti1, Antonio Bruno1, Alessandra Colamatteo3,Claudio Procaccini1,3, Giuseppe Matarese3
P030
Long-term stimulation of PPARα relieves core symptoms of autism spectrumdisorder in the rat valproic acid mode
Simona Scheggi1, Giulia Braccagni1, Maria Graziella De Montis1, FrancescaGuzzi2Guzzi2, Marco Parenti2, Carla Gambarana1 (1Siena, 2Milan)
P032
In vivo genetic ablation of metabotropic glutamate receptor type 5 slows downdisease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis
Carola Torazza, Tiziana Bonifacino, Marco Milanese, Francesca Provenzano,Aldamaria Puliti, Giambattista Bonanno (Genoa)
P034
Searching single nucleotide variations related to Neuroleptic Malignant Syndrome susceptibility
Martina Toffol, Veronica Cattaneo, Barbara Balestra, Elena Brambilla, ValeriaM. Petrolini, Fiorenzo A. Peverali, Ornella Pastoris (Pavia
P035
Evaluation of the safety profile of rotavirus vaccines: a pharmacovigilance analysis on US and European data
Giulia Bonaldo1, Roberta Noseda2, Alessandro Ceschi3, Alberto Vaccheri1,,Domenico Motola1(1Bologna, 2Lugano - Switzerland, 3Zurich - Switzerland)
P036
Shift from chronic migraine to episodic migraine status in a long-term phase 3 study of galcanezumab
Holland Detke1, Kathleen A. Day1, Sarah Lipsius2, Sheena K. Aurora1, Nada, NadaA. Hindiyeh3, Hans-Christoph Diener4, Amalia Antenori5 (1Indianapolis - USA, 2Raleigh - USA, 3Stanford - USA, 4Essen - Germany, 5Rome)
P038
Evaluation of cardiovascular risks in adult patients with episodic or chronicmigraine treated with galcanezumab: data from three phase 3, randomized,double-blind, placebo-controlled studies
Tina M. Oakes1, Richard Kovacs1, Noah Rosen2, Erin Doty1, Phebe Kemmer1, Phebe Kemmer1,Sheena K. Aurora1, Angelo Camporeale1, Amalia Antenori3 (1Indianapolis -USA, 2Hempstead - USA, 3Rome)
P039
Safety and cost of drugs prescribed according to Law 648/96
Laura Longo, Lucia Gozzo, Daniela Cristina Vitale, Giuseppe Benfatto,Filippo Drago (Catania)
P040
Adverse events detected in emergency room of an University Hospital
Costanza Furlanetto1, Agnese Princi1, Irene D’Este1, Sara Dereani2, Paola, PaolaRossi2, Irene Fregonese1, Catia Tavano1, Ranieri Giuseppe Cravero1, GermanaModesti1 (1Udine, 2Trieste)
P041
Safety and tolerability of antipsychotic drugs in paediatric patients: data from an active pharmacovigilance study
Giuseppe Cicala1, Maria Antonietta Barbieri1, Vincenza Santoro1, EvaGermanò1Germanò1, Carmela Tata2, Valentina Colucci3, Francesca Vanadia4, FlaviaDrago4, Carmelita Russo5, Paola Maria Cutroneo1, Edoardo Spina1 (1Messina, 2Siracusa, 3Enna, 4Palermo, 5Ca
P042
Adverse drug reactions during biologic therapy in dermatological disease: real life data from the pharmacovigilance project in Calabria and Sicilia regions
Giuseppe Cicala1, Maria Antonietta Barbieri1, Vincenza Santoro1Giovambattista De Sarro1, Valeria Papaianni2, Valeria Papaianni2, Maria Antonietta Barbieri2,Luigi Bennardo1, Stefano Dastoli1, Maria Diana Naturale1, Eugenio Donatodi Paola1, Serafinella Patr
P043
Adverse drug reactions during biologic therapy in inflammatory bowel disease:real life data from the pharmacovigilance project in Calabria and Sicilia regions
Maria Diana Naturale1, Roberta Roberti1, Caterina Palleria1, MariaAntonietta Barbieri2Antonietta Barbieri2, Tiziana Larussa1, Rocco Spagnuolo1, Francesco Luzza1,Patrizia Doldo1, Ada Vero1, Antonia Manti1, Valentina Pisana2, Walter Fries2,Gianluca Trifirò
P044
Monitoring adverse event by ipoglycemic drugs in Calabria region
Caterina Palleria, Caterina De Sarro, Ada Vero, Roberta Roberti, Giovanna Mangano, Eugenio Donato di Paola, Agostino Gnasso, Concetta Irace, Emilio Russo (Catanzaro)
P045
Safety profile of biologics in rheumatologic diseases in a real world setting in Southern Italy: a prospective pharmacovigilance study
Maria Antonietta Barbieri1 , Caterina Palleria2 , Antonia Manti2 , Giuseppe Cicala1 , Elisabetta Gerratana1 , Fabiola Atzeni1 , Emilio Russo2 , Giovambattista De Sarro2 , Edoardo Spina1 ( 1 Messina, 2 Catanzaro)
P046
Pharmacovigilance of sleep aids, an Italian experience
Paolo Pellegrino, Elena Giacomoni, Andrea Chiarenza, Roberto Monteverdi,Daniela Facchinello, Maria Chiara Uboldi (Milan)
P047
25-hydroxy vitamin D detection in subjects with headache using different methodogical approaches
Luca Gallelli, Andzelika Michniewicz, Erika Cione, Stefania Zampogna, Francesco Peltrone, Rosario Iannacchero, Giovambattista De Sarro (Catanzaro)
P048
Pharmacovigilance in child neuropsychiatry: multidisciplinary project at the IRCCS Burlo Garofalo
Marta Paulina Trojniak, Maria Sole Giurin, Giulia Fornasier, Caterina Zanus, Anna Arbo, Alessandra Maestro, Davide Zanon, Marco Carrozzi (Trieste)
P049
Evaluation of Adverse Drug Reaction Reporting in the Sicilian Regional Pharmacovigilance Center over a 3-year period
Paola Maria Cutroneo, Nicola Pellegrino, Maria Antonietta Barbieri, Giuseppe Cicala, Giulia Maria Di Natale, Pierangela Irrera, Emanuele Leotta, Edoardo Spina (Messina)
P050
A six-years active pharmacovigilance study of adverse drug reactions causing children admission to the Emergency Department in Southern Italy
Paola Maria Cutroneo, Nicola Pellegrino, Maria Antonietta Barbieri, Giuseppe Cicala, Giulia Maria Di Natale, Pierangela Irrera, Emanuele Leotta, Edoardo Spina (Messina)
P051
A six-years active pharmacovigilance study of adverse drug reactions causing children admission to the Emergency Department in Southern Italy
Chiara Nasso1 , Anna Mecchio1 , Michelangelo Rottura1 , Elisa Bongiorno1 , Teresa Arrigo1 , Vincenzo Arcoraci1 , Francesca Menniti Ippolito2 , Domenica Altavilla1 ( 1 Messina, 2 Rome)
P051
Interaction between paracetamol and lamotrigine: new insights from the FDA
Giulia Mosini1 , Carla Carnovale1 , Michele Gringeri1 , Vera Battini1 , Faizan Mazhar1 , Marco Pozzi2 , Emilio Clementi1 , Sonia Radice1 ( 1 Milan, 2 Lecco)
P052
Bullous pemphigoid induced by dipeptidyl peptidase-4 (DPP-4) inhibitors: a Pharmacovigilance-Pharmacodynamic/Pharmacokinetic assessment through an analysis of the VigiBase®
Giulia Mosini1 , Carla Carnovale1 , Faizan Mazhar1 , Elena Arzenton2 , Ugo Moretti2 , Marco Pozzi3 , Olivia Leoni1 , Marco Scatigna1 , Emilio Clementi1 , Sonia Radice1 ( 1 Milan, 2 Verona, 3 Lecco)
P053
Analysis of drug-drug interactions based on administrative Emilia Romagna Healthcare databases
Sofia Burato1 , Luca Leonardi2 , Emanuel Raschi1 , Chiara Ajolfi3 , Manuela Baraghini4 , Antonella Chiarello5 , Valentina Delmonte6 , Lucio Di Castri7 , Monia Donati1 , Antonella Fadda5 , Daniela Fedele8 , Alessandra Ferretti9 , Laura Gabrielli9 , Silvia
P054
Efficacy of tumor necrosis factor-alpha therapy in the management of paediatric perianal Crohn’s disease: a systematic review
Vera Battini, Faizan Mazhar, Anna Maffioli, Gloria Zaffaroni, Giulia Mosini, Piergiorgio Danelli, Emilio Clementi, Sonia Radice, Carla Carnovale (Milan)
P055
Correlation between dizziness and levothyroxine inefficacy: new insights from the FDA Adverse Event Reporting System (FAERS) database
Vera Battini, Faizan Mazhar, Giulia Mosini, Andrea Vicenzi, Emilio Clementi, Sonia Radice, Carla Carnovale (Milan)
P056
Program of “Oncovigilance
Francesco Iannello, Valentina Manzo, Clementina Savastano, Martina Torsiello, Emanuela De Bellis, Francesca Colucci, Teresa Iannaccone, Francesco Sabbatino, Amelia Filippelli, Valeria Conti (Salerno)
P057
Janus kinase inhibitors and cardiovascular events in rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials
Emanuel Raschi1 , Nicolò Bendinelli1 , Ippazio Cosimo Antonazzo1 , Jacopo Ciaffi1 , Olga Addimanda1 , Francesco Salvo2 , Christophe Richez2 , Elisabetta Poluzzi1 , Fabrizio De Ponti1 ( 1 Bologna, 2 Bordeaux - France)
P058
Social adverse drug reactions: a pharmacovigilance-pharmacodynamic assessment through the FDA adverse event reporting system
Michele Fusaroli, Emanuel Raschi, Ippazio Cosimo Antonazzo, Fabrizio De Ponti, Elisabetta Poluzzi (Bologna)
P059
Measurement of Δ9-tetrahydrocannabinol and cannabidiol of medical cannabis in plasma samples and decoctions for therapeutic drug monitoring
Carmen Fucile, Sebastiano Barco, Luca Manfredini, Elisa De Grandis, Marcella Gherzi, Antonietta Martelli, Gino Tripodi, Giuliana Cangemi, Francesca Mattioli (Genoa)
P060
The role of hypoxia in a cellular model of glioblastoma
Giulia Sita1 , Fabiana Morroni1 , Agnese Graziosi1 , Andrea Tarozzi2 , Patrizia Hrelia1 ( 1 Bologna, 2 Rimini)
P062
Estrogenic regulation of endothelial glycolytic pathway
Carlotta Boscaro, Annalisa Trenti, Chiara Scapin, Lucia Trevisi, Andrea Cignarella, Chiara Bolego (Padua)
P063
Role of innate immunity receptors in the process of crystal phagocytosis
Chiara Baggio, Anna Scanu, Francesca Mastrotto, Roberta Ramonda, Paolo Sfriso, Andrea Cignarella, Francesca Oliviero (Padua)
P064
Investigation into Blue LED light effects on cell metabolism, proliferation rate and ionic currents in cultured human keloid fibroblasts: a possible involvement of adenosine A2A receptors
Giada Magni1 , Federica Cherchi2 , Elisabetta Coppi2 , Marco Fraccalvieri3 , Felicita Pedata2 , Roberto Pini1 , Anna Maria Pugliese2 , Francesco S. Pavone1 , Francesca Rossi1 ( 1 Sesto Fiorentino, 2 Florence, 3 Turin)
P065
CD73 expression and activity in serum of melanoma patients and healthy donors
Roberta Turiello1 , Mariaelena Capone2 , Gabriele Madonna2 , Ester Simeone2 , Aldo Pinto1 , Paolo Antonio Ascierto2 , Silvana Morello1 ( 1 Salerno, 2 Naples)
P066
Selective placental growth factor (PlGF) inhibition: a novel pharmacological approach in diabetic retinopathy
Francesca Lazzara, Annamaria Fidilio, Chiara B. Maria Platania, Federica Conti, Salvatore Salomone, Filippo Drago, Claudio Bucolo (Catania)
P067
Long-lasting antinociceptive effects of Ammonium Glycyrrhizinate in mice
Paola Minosi1 , Federica Raucci2 , Amalia Di Giannuario1 , Maria Giovanna Chini3 , Simona De Vita3 , Giuseppe Bifulco3 , Francesco Maione2 , Nicola Mascolo2 , Stefano Pieretti1 ( 1 Rome, 2 Naples, 3 Salerno)
P068
The arylpiperazinylalkyl pyridazinone ET1 as a potent antinociceptive agent after oral administration in mice
Francesca Marzoli1 , Francesco Maione2 , Mariantonella Colucci1 , Paola Minosi1 , Amalia Di Giannuario1 , Federica Raucci2 , Nicola Mascolo2 , Maria Paola Giovannoni3 , Stefano Pieretti1 ( 1 Rome, 2 Naples, 3 Sesto Fiorentino)
P069
Stemness marker aldehyde dehydrogenase 1A1(ALDH1A1) promotes tumor angiogenesis in breast cancer cells
Valerio Ciccone, Sandra Donnini, Lucia Morbidelli, Marina Ziche (Siena)
P070
Evidence that genes involved in serine/threonine kinase activity are associated with both bipolar disorder and high BMI
Claudia Pisanu1 , Michael J. Williams2 , Diana Maria Ciuculete2 , Gaia Olivo2 , Maria Del Zompo1 , Alessio Squassina1 , Helgi B. Schiöth2 ( 1 Cagliari, 2 Uppsala - Sweden)
P071
Ultrasonic communication deficits in a mouse model of neurodevelopmental disorders and effect of maternal enrichment
Marika Premoli, Sara Anna Bonini, Andrea Mastinu, Giuseppina Maccarinelli, Giulia Paiardi, Francesca Aria, Maurizio Memo (Brescia)
P072
Telomeres length in genetically diagnosed familial hypercholesterolemia
Andrea Baragetti, Fabio Pellegatta, Stefania Cicolari, Veronica Zampoleri, Liliana Grigore, Angela Pirillo, Giuseppe Danilo Norata, Alberico Luigi Catapano (Milan
P073
Pharmacological studies for treatment of space-related disorders
Shirley Genah1 , Valerio Ciccone1 , Lucia Morbidelli1 , Francesca Cialdai2 , Monica Monici3 ( 1 Siena, 2 Florence)
P075
An ER-to-mitochondria Ca2+-shuttling unravelled by absinthin, a bitter taste receptor hTAS2R46 agonist
Maria Talmon, Silvia Rossi, Dmitry Lim, Federica Pollastro, Patrizia Marotta, Armando A. Genazzani, Luigia G. Fresu (Novara)
P076
Mesoglycan induces keratinocyte activation by triggering syndecan-4 pathway and the formation of the annexin A1/S100A11 complex
Valentina Bizzarro1 , Raffaella Belvedere1 , Emanuela Pessolano1 , Luca Parente1 , Mauro Perretti2 , Antonello Petrella1 ( 1 Salerno, 2 London - United Kingdom)
P077
Chloride intracellular channel 1 inhibition dictates antitumor effects of old and new biguanide compounds in glioblastoma stem cells
Federica Barbieri1 , Alessia Bosio1 , Ivan Verduci2 , Maria Grazia Cattaneo2 , Laura M. Vicentini2 , Michele Mazzanti2 , Tullio Florio1 ( 1 Genoa, 2 Milan)
P078
Effects of hexarelin on the modulation of apoptosis pathway induced by hydrogen peroxide
Ramona Meanti, Laura Molteni, Laura Rizzi, Elena Bresciani, Vittorio Locatelli, Antonio Torsello (Monza)
P079
Glucocorticoid-induced leucine zipper is required for hematopoietic stem cell function
Zenobio Viana de Barros, Sara Flamini, Stefano Bruscoli, Graziella Migliorati, Oxana Bereshchenko, Carlo Riccardi (Perugia)
P080
Mitophagic/autophagic inhibitors as new strategy to overcome cisplatin resistance in cancer
Veronica Cocetta, Caterina Vianello, Eugenio Ragazzi, Luca Scorrano, Marta Giacomello, Monica Montopoli (Padua)
P081
The role of FKBP5 polymorphisms in resistance to developmental change of executive functions in children with persistent asthma
Chiara Colliva, Barbara Maria Bergamini, Cristina Benatti, Johanna Maria Catharina Blom (Reggio Emilia)
P082
Cholesterol efflux capacity of cerebrospinal fluid is impaired in Alzheimer’s Disease
Cinzia Marchi1 , Maria Pia Adorni1 , Paolo Caffarra1 , Nicoletta Ronda1 , Marco Spallazzi1 , Federica Barocco1 , Daniela Galimberti2 , Franco Bernini1 , Francesca Zimetti1 ( 1 Parma, 2 Milan)
P083
The importance of a careful analysis of interactions between herbal products and medicines
Salvatore Bianco, Giulia Matteucci, Alfredo Nunziata (Pomezia)
P084
Long-lasting anti-inflammatory effects of ammonium glycyrrhizinate: an integrated study of pharmacology and computational analysis
Federica Raucci1 , Paola Minosi2 , Amalia Di Giannuario2 , Maria Giovanna Chini3 , Simona De Vita3 , Giuseppe Bifulco3 , Francesco Maione1 , Stefano Pieretti2 , Nicola Mascolo1 ( 1 Naples, 2 Rome, 3 Salerno)
P085
Herb and spice mediated interactions in oncologic patients treated with chemotherapy
Francesca Turco, Andrea Elio Sprio, Ilenia Bertaggia, Tiziana Armando, Silvana Storto, Sarah Allegra, Silvia De Francia, Libero Ciuffreda, Maria Valentina Mussa (Turin)
P086
nitial biological validation of herbal drugs from Vietnamese traditional medicine
Sabrina Adorisio1 , Isabella Muscari2 , Carlo Riccardi2 , Domenico Delfino2 ( 1 Foligno, 2 Perugia)
P087
Phytosomal preparation of Centella asiatica L. improves the cognitive performance by modulating neuroplastic mechanisms
Paola Brivio, Giulia Sbrini, Enrico Sangiovanni, Giorgio Racagni, Stefano Piazza, Mario Dell’Agli, Francesca Calabrese (Milan)
P089
Caryophyllane sesquiterpenes reverse sorafenib-chemoresistance through Pgp and STAT3 pathways in liver cancer cells
Silvia Di Giacomo, Margherita Eufemi, Elisabetta Rubini, Marco Gullì, Gabriela Mazzanti, Antonella Di Sotto (Rome)
P090
Protective effects of cyanidin-3-O-glucoside against palmitate-induced insulin resistance in human SGBS hypertrophic adipocytes
Maria Sofia Molonia1 , Francisc Villarroya2 , Tania Quesada-López2 , Claudia Muscarà1 , Romina Bashllari1 , Antonio Speciale1 , Antonina Saija1 , Francesco Cimino1 ( 1 Messina, 2 Barcelona - Spain)
P091
Effect of cannabidivarin, a non-euphoric phytocannabinoid, on murine intestinal inflammation and biopsies of ulcerative colitis paediatric patients
Tommaso Venneri1 , Ester Pagano1 , Barbara Romano1 , Fabio Arturo Iannotti2 , Olga Alessandra Parisi1 , Maria D’Armiento1 , Lorena Coretti1 , Marianna Lucafò3 , Gabriele Stocco3 , Francesca Lembo1 , Raffaele Capasso1 , Vincenzo Di Marzo2 , Angelo Anton
P092
Effect of repeated treatment with olive-based preparations on colitis model in rats
Carmen Parisio, Laura Micheli, Elena Lucarini, Alessandra Toti, Nadia Mulinacci, Daniele Bani, Lorenzo Di Cesare Mannelli, Carla Ghelardini (Florence)
P093
Anti-inflammatory effect of a flavonoid-rich extract of orange juice in an in vivo model of Vibrio anguillarum-induced enteritis in zebrafish
Caterina Russo, Giuseppe Montalbano, Alessandro Maugeri, Laura Musumeci, Santa Cirmi, Giovanni Enrico Lombardo, Antonino Germanà, Michele Navarra (Messina)
P094
Effect of a flavonoid-rich extract of orange juice on weight management in an in vivo model of obese zebrafish
Alessandro Maugeri, Giuseppe Montalbano, Laura Musumeci, Santa Cirmi, Caterina Russo, Giovanni Enrico Lombardo, Antonino Germanà, Michele Navarra (Messina)
P095
Melanocortin receptor 5 (MC5R) cardio-protection in high glucose-induced H9c2 hypertrophy
Maria Consiglia Trotta1 , Rosa Maisto1 , Nicola Alessio1 , Anca Hermenenan2 , Michele D’Amico1 ( 1 Naples, 2 Arad - Romania)
P096
The citrus flavonoid naringenin slows down myocardial ageing by increasing sirtuin 1 enzyme expression in mice
Eugenia Piragine1 , Lara Testai1 , Alma Martelli1 , Valentina Citi1 , Lorenzo Flori1 , Ilaria Piano1 , Maria Claudia Gargini1 , Andrea Pirone1 , Vincenzo Miragliotta1 , Lorenzo Di Cesare Mannelli2 , Carla Ghelardini2 , Maria Cristina Breschi1 , Vincenzo C
P097
Sex differences in rat platelet aggregation induced by different stimuli
Rossella Bilancia1 , Elisabetta Caiazzo1 , Simona Pace2 , Fabiana Troisi2 , Antonietta Rossi1 , Carla Cicala1 , Oliver Werz2 , Armando Ialenti1 ( 1 Naples, 2 Jena - Germany)
P098
The novel H2 S-donor ISOTHIA25 promotes cardioprotective effect against myocardial ischemia/reperfusion injury in rat hearts and reduction of oxidative stress in H9c2 cells
Era Gorica1 , Lorenzo Flori1 , Valentina Citi1 , Eugenia Piragine1 , Beatrice Severino2 , Angela Corvino2 , Alma Martelli1 , Lara Testai1 , Giuseppe Caliendo2 , Vincenzo Calderone1 ( 1 Pisa, 2 Naples)
P099
The anti-atherogenic role of sphingosine 1-phosphate and sphingosine 1-phospate receptor 3 in the reverse cholesterol transport
Enrica Scalera1 , Bianca Papotti1 , Ilaria Zanotti1 , Daniela Greco1 , Simone Battista1 , Franco Bernini1 , Jerzy-Roch Nofer2 , Manuela Simoni3 , Francesco Potì1 ( 1 Parma, 2 Münster - Germany, 3 Modena)
P100
Resolvin D1 attenuates the organ injury associated with hemorrhagic shock
Fausto Chiazza1 , Regina Sordi2 , Debora Collotta1 , Giuseppe Migliaretti1 , Romain A. Colas2 , Paul Vulliamy2 , Karim Brohi2 , Jesmond Dalli2 , Massimo Collino1 , Christoph Thiemermann2 ( 1 Turin, 2 London - United Kingdom)
P101
Human left atrial dilation is associated to increased expression of type-1 Hyperpolarization Cyclic-Nucleotide gated channel and MinK-related peptide 1 subunit: implications for atrial electrophysiological remodeling
Manuela Gencarelli1 , Valentina Balducci1 , Benedetta Fabrizi1 , Valentina Spinelli1 , Matteo Cameli2 , Sergio Mondillo2 , Alessandro Mugelli1 , Laura Raimondi1 , Elisabetta Cerbai1 , Laura Sartiani1 ( 1 Florence, 2 Siena)
P102
MicroRNA-34a silencing regulates myocardial fibrosis in a rat model of doxorubicin cardiotoxicity
Anna Cozzolino, Elena Piegari, Loreta Pia Ciuffreda, Donato Cappetta, Antonella De Angelis, Konrad Urbanek, Liberato Berrino (Naples)
P104
β-3 adrenergic receptor activation causes hydrogen sulfide production via cystathionine γ-lyase in human urothelium
Domenico Vanacore, Emma Mitidieri, Ferdinando Fusco, Vincenzo Mirone, Roberta d’Emmanuele di Villa Bianca, Giuseppe Cirino, Raffaella Sorrentino (Naples)
P105
Effects of mexiletine on the sodium channel overlap syndrome mutation SCN5A-1795insD
Chiara Palandri1 , Giovanna Nasilli2 , Raffaele Coppini1 , Laura Sartiani1 , Vincent Portero2 , Elisabetta Cerbai1 , Carol Ann Remme2 , Simona Casini1 ( 1 Florence, 2 Amsterdam - NL)
P106
Off-label uses in pediatrics: focus on drugs of the cardiovascular system
S. Cammarata, G. Capone, N. Lombardi, L. Pani, A. Mugelli (Rome)
P107
Dopamine receptor signalling in pancreatic β-cells
Marco Carli, Stefano Aringhieri, Shivakumar Kolachalam, Francesca Vaglini, Michela Novelli, Marco Scarselli (Pisa)
P108
Pilot study on comparative profiling of biofluids (plasma, urine and saliva) from metabolically healthy and metabolically unhealthy obese subjects
Debora Collotta1 , Chiara Cordero1 , Jared Q. Gerlach2 , Erica Liberto1 , Fausto Chiazza1 , Marta Cialiè Rosso1 , Chiara Mele3 , Stefania Mai3 , Stephen E. Reichenbach4 , Qingping Tao4 , Marie Le Berre2 , Raffaella Mastrocola5 , Manuela Aragno5 , Lokesh
P109
Eating disorders in athletes: from risk managing to therapy
Walter Milano1 , Anna Capasso2 ( 1 Naples, 2 Salerno)
P110
Mediterranean diet: the right way to longevity?
Walter Milano1 , Anna Capasso2 ( 1 Naples, 2 Salerno)
P111
Modulation of the cross-talk between NLRP3 inflammasome signalling and endothelial transcription factor EB (TFEB): a new strategy to halt inflammation and improve poor wound healing in diabetes
Natasha Irrera1 , Federica Mannino1 , Alessandra Bitto1 , Michele Colonna1 , Anna Valeria Vergoni2 , Domenica Altavilla1 , Salvatore Guarini2 , Francesco Squadrito1 ( 1 Messina, 2 Modena)
P112
Bilastine preserves the glomerular junctional integrity in a murine model of diabetic nephropathy
Roberta Verta1 , Cristina Grange1 , Maura Gurrieri1 , Sara Borga1 , Patrizia Nardini2 , Monica Argenziano1 , Corrado Ghè1 , Roberta Cavalli1 , Elisa Benetti1 , Gianluca Miglio1 , Benedetta Bussolati1 , Alessandro Pini2 , Arianna Carolina Rosa1 ( 1 Turin,
P113
Oxytocin-increase in bone, soleus muscle and hypothalamic paraventricular nuclei regulates the response to cold stress in mice exerting phenotypedependent protective effects towards slow-twitch muscle
Claudia Camerino1 , Elena Conte1 , Adele Romano2 , Michela De Bellis1 , Marialuisa de Ceglia2 , Maria Rosaria Carratù1 , Silvana Gaetani2 , Domenico Tricarico1 ( 1 Bari, 2 Rome)
P114
miRNA-218 Targets Lipin-1 and Glucose Transporter Type 4 genes in 3T3-L1 Cells Treated with Lopinavir/Ritonavir
Elena Bresciani1 , Cecilia Saletti1 , Nicola Squillace1 , Laura Rizzi1 , Laura Molteni1 , Ramona Meanti1 , Robert J. Omeljaniuk2 , Giuseppe Biagini3 , Andrea Gori4 , Vittorio Locatelli1 , Antonio Torsello1 ( 1 Monza, 2 Thunder Bay - Canada, 3 Modena, 4 Mi
P115
Diseases and health risks associated with obesity
Walter Milano1 , Anna Capasso2 ( 1 Naples, 2 Salerno)
P116
Gender dysphoria, eating disorders and body image
Walter Milano1 , Anna Capasso2 ( 1 Naples, 2 Salerno)
P117
Nutrition and nutrigenomics
Anna Capasso, Mario Felice Tecce (Salerno)
P118
Gliadin and adipose inflammation, anti-inflammatory and protective effects of diet-derived flavonoids
Federica Mannino, Natasha Irrera, Giovanni Pallio, Domenica Altavilla, Francesco Squadrito, Alessandra Bitto (Messina)
P119
Phytochemical composition and biological activities of two Cannabis sativa L. biotypes extracts
Claudia Muscarà1 , Antonella Smeriglio1 , Domenico Trombetta1 , Giuseppina Mandalari1 , Erminia La Camera1 , Gianpaolo Grassi2 , Clara Circosta1 ( 1 Messina, 2 Rovigo)
P120
Effects of Oleuropein on colon cancer progression in vitro. A preliminary report
Carla Flandina1 , Marilena Crescimanno1 , Maria Vittoria Sepporta2 , Gaetano Leto1 ( 1 Palermo, 2 Lausanne - Switzerland)
P121
Whey proteins reduce appetite, stimulate anorexigenic gastrointestinal peptides and improve glucometabolic homeostasis in young obese women
Antonello E. Rigamonti1 , Roberto Leoncini3 , Claudia Casnici1 , Ornella Marelli1 , Alessandra De Col2 , Sofia Tamini2 , Elisa Lucchetti2 , Sabrina Cicolini2 , Laura Abbruzzese2 , Silvano G. Cella1 , Alessandro Sartorio2 ( 1 Milan, 2 Verbania, 3 Siena)
P122
Acute administration of capsaicin increases resting energy expenditure in young obese subjects without affecting energy intake, appetite and circulating levels of orexigenic/anorexigenic peptides
Antonello E. Rigamonti1 , Claudia Casnici1 , Ornella Marelli1 , Alessandra De Col2 , Sofia Tamini2 , Elisa Lucchetti2 , Gabriella Tringali2 , Roberta De Micheli2 , Laura Abbruzzese2 , Mauro Bortolotti3 , Silvano G. Cella1 , Alessandro Sartorio2 ( 1 Milan,
P123
Herbal dietary supplements used in weight control and dyslipidemia: preliminary study of pharmacies data sales
Olta Allkanjari, Silvia Di Giacomo, Gabriela Mazzanti, Francesca MennitiIppolito, Tito Piccioni, Annabella Vitalone (Rome)
P124
Records of exposures to plant and plant-derived products collected by the Poison Control Center of Policlinico Umberto I - Sapienza University of Rome
Annabella Vitalone, Matilde Pasquarelli, Antonella Di Sotto, M. Caterina Grassi, Gabriela Mazzanti (Rome)
P125
Chronic low back pain and SPA therapy
Maria Costantino1 , Valeria Conti1 , Antonella Guida2 , Walter Filippelli2 , Francesco Marongiu2 , Mario Farroni1 , Amelia Filippelli1 ( 1 Salerno, 2 Naples)
P127
Purple corn extract as adjuvant therapy for the prevention and treatment of trigeminal pain: role of microglia and of the gut microbiota
Giulia Magni1 , Alessandra Marinelli1 , Daniele Riccio2 , Davide Lecca1 , Christian Milani3 , Marco Ventura3 , Mariapia Abbracchio1 , Chiara Tonelli1 , Katia Petroni1 , Stefania Ceruti1 ( 1 Milan, 2 Aalborg - Denmark, 3 Parma)
P128
Effect of enrichment with different Crocus spp stigmas on antioxidant properties of wheat flour pasta
Cristina Occhiuto1 , Maria Sofia Molonia1 , Romina Bashllari1 , Luana Pulvirenti2 , Francesco Cimino1 , Antonio Speciale1 , Antonina Saija1 , Giuseppe Ruberto2 , Laura Siracusa2 , Mariateresa Cristani1 ( 1 Messina, 2 Catania)
P129
Bioavailability of formulations containing Curcuma longa L. and/or Centella asiatica L. in rats
Marco Fumagalli, Paola Brivio, Flavio Giavarini, Enrico Sangiovanni, Giulia Sbrini, Stefano Piazza, Francesca Calabrese, Giorgio Racagni, Donatella Caruso, Mario Dell’Agli (Milan)
P130
Leaf extracts and ellagitannins from chestnut (Castanea sativa Mill.) inhibit IL-8 release in H. pylori-infected gastric epithelial cells
Stefano Piazza1 , Enrico Sangiovanni1 , Urska Vrhovsek2 , Marco Fumagalli1 , Saba Khalilpour1 , Domenico Masuero2 , Luca Colombo3 , Fulvio Mattivi2 , Emma De Fabiani1 , Mario Dell’Agli1 , Giulia Martinelli1 , Andrea Magnavacca1 (1 Milan, 2 San Michele a
P131
Innovative approach to recurrent vaginitis
Rosa Conte1 , Ettore Cicinelli2 , Viviana Giannuzzi1 , Annalisa Landi1 , Flavia Laforgia3 , Maria De Angelis1 , Bianca Tempesta1 , Mariagrazia Felisi1 , Rosa Padula1 , Maria Grazia Roselli3 , Vanessa Garofalo3 , Fedele Bonifazi1 ( 1 Valenzano, 2 Bari, 3 C
P132
The role of mitochondrial SIRT3 in neuropathic pain
Sara Ilari1 , Luigino Antonio Giancotti2 , Filomena Lauro1 , Valentina Malafoglia1 , Micaela Gliozzi1 , Marco Tafani3 , Massimo Fini3 , Vincenzo Mollace1 , Daniela Salvemini2 , Carolina Muscoli1 ( 1 Catanzaro, 2 Saint Louis - USA, 3 Rome)
P133
Nature-inspired hybrids targeting Nrf2-pathway exert anti-inflammatory effect on human monocytic cell line
Francesca Fagiani1 , Michele Catanzaro1 , Irene Romanoni1 , Marco Racchi1 , Michela Rosini2 , Stefano Govoni1 , Cristina Lanni1 ( 1 Pavia, 2 Bologna)
P134
Evaluation of the ergogenic effect of an amino acid-based dietary supplement in a murine model of physiological exercise
Francesca Sanarica1 , Paola Mantuano1 , Brigida Boccanegra1 , Michela De Bellis1 , Antonietta Mele1 , Ornella Cappellari2 , Elena Conte1 , Giulia Maria Camerino1 , Gianluca Bianchini3 , Andrea Aramini1 , Annamaria De Luca1 ( 1 Bari, 2 Manchester - United
P135
Anthocyanin rich extract ameliorates palmitic acid-induced inflammation and hypertrophy in 3T3-L1 murine adipocytes
Claudia Muscarà, Cristina Occhiuto, Maria Sofia Molonia, Romina Bashllari, Francesco Cimino, Antonina Saija, Antonio Speciale (Messina)
P136
Effects of a seed extract of Eruca sativa Mill. in an experimental model of metabolic syndrome
Lorenzo Flori1 , Eugenia Piragine1 , Lara Testai1 , Valentina Citi1 , Alma Martelli1 , Andrea Pirone1 , Vincenzo Miragliotta1 , Roberto Matteo2 , Luisa Ugolini2 , Eleonora Pagnotta2 , Luca Lazzeri2 , Lorenzo Di Cesare Mannelli3 , Carla Ghelardini3 , Vince
P137
Antioxidant effect of resveratrol in a mouse model of chronic ethanol addiction
Carla Petrella, Valentina Carito, Fausta Natella, Giampiero Ferraguti, Mauro Ceccanti, Antonio Greco, Massimo Ralli, Marco Fiore (Rome)
P138
Studying the chemopreventive properties of inflorescences from industrial hemp variety Felina 32 in relation to the phenolic and terpenoid composition
Studying the chemopreventive properties of inflorescences from industrial hemp variety Felina 32 in relation to the phenolic and terpenoid composition
P139
Effects of bud extracts from Tilia tomentosa Moench in central nervous system of mice: gender and age-dependency
Massimo Grilli1 , Guendalina Olivero1 , Federica Turrini1 , Giulia Vallarino1 , Matteo Vergassola1 , Dario Donno2 , Gabriele Loris Beccaro2 , Paola Zunin1 , Raffaella Boggia1 , Anna Pittaluga1 ( 1 Genoa, 2 Turin)
P140
In vitro bioaccessibility of an anthocyanin rich standardized extract from bilberry and blackcurrant
Romina Bashllari1 , Maria Sofia Molonia1 , Claudia Muscarà1 , Antonio Speciale1 , Antonina Saija1 , Mariateresa Cristani1 , Peter Wilde2 , Francesco Cimino1 ( 1 Messina, 2 Norwich - United Kingdom)
P141
Meripilus giganteus ethanolic extract exhibits pro-apoptotic and antiproliferative effects in leukemic cell lines
Monia Lenzi1 , Veronica Cocchi1 , Maria Cristina Barbalace2 , Patrizia Hrelia1 , Marco Malaguti2 , Silvana Hrelia2 ( 1 Bologna, 2 Rimini)
P142
Effects of bergamot essential oil bergaptene-free in in vivo experimental models of inflammation and pain
Laura Musumeci, Giovanni Enrico Lombardo, Alessandro Maugeri, Caterina Russo, Carmen Mannucci, Santa Cirmi, Michele Navarra (Messina)
P143
Modulatory effects of SERMs on macrophage phenotypic activation
Giovanna Pepe, Gian Enrico Rovati, Federica Mornata, Massimo Locati, Adriana Maggi, Elisabetta Vegeto (Milan)
P144
Novel nonsteroidal anti-inflammatory drug and carbonic anhydrase inhibitor hybrids for the treatment of inflammation
Laura Lucarini, Mariaconcetta Durante, Silvia Sgambellone, Daniele Innocenti, Alessio Nocentini, Silvia Bua, Claudiu T. Supuran, Emanuela Masini (Florence)
P145
The neuroprotective effects of micronized PEA (PEA-m) formulation on diabetic peripheral neuropathy in mice
Alessio Filippo Peritore, Daniela Impellizzeri, Rosalba Siracusa, Enrico Gugliandolo, Roberta Fusco, Marika Cordaro, Rosalia Crupi, Ramona D’Amico, Salvatore Cuzzocrea, Rosanna Di Paola (Messina)
P146
A possible cross-talk between histamine H4 receptor (H4 R) and A3 adenosine receptor (A3 AR) on CD4+ T cells in resolution of neuropathic pain states
Mariaconcetta Durante1 , Laura Lucarini1 , Carla Ghelardini1 , Lorenzo Di Cesare Mannelli1 , Robin Thurmond2 , Emanuela Masini1 (Florence, 2 San Diego - USA)
P147
Experimental colitis protection by a small molecule antagonizing Eph/ephrin system
Carmine Giorgio, Simone Palese, Massimiliano Tognolini, Riccardo Castelli, Lisa Flammini, Miriam Corrado, Elisabetta Barocelli, Simona Bertoni (Parma)
P148
Pharmacological modulation of sphingosine-1-phosphate receptors in mesenteric ischemia-reperfusion
Simone Palese, Carmine GIorgio, Francesco Potì, Valentina Vivo, Irene Zini, Vigilio Ballabeni, Simona Bertoni, Elisabetta Barocelli (Parma)
P149
The protective effects of micronized Palmitoylethanolamide formulation on postoperative pain in rats
Enrico Gugliandolo, Alessio Filippo Peritore, Rosalba Siracusa, Roberta Fusco, Ramona D’Amico, Marika Cordaro, Daniela Impellizzeri, Rosalia Crupi, Rosanna Di Paola, Salvatore Cuzzocrea (Messina)
P150
Extracellular Nicotinamide Phosphoribosyl Transferase (eNAMPT) promotes macrophage polarization and migration
Giorgia Colombo1 , Cristina Travelli2 , Chiara Porta1 , Armando A. Genazzani1 ( 1 Novara, 2 Pavia)
P151
The role of thiopurine methyltransferase promoter methylation in azathioprine biotransformation in early-onset pediatric patients with inflammatory bowel dis
Sofia Pagarin1 , Marianna Lucafò2 , Giuliana Decorti1 , Gabriele Stocco1 , Susan Thompson3 , Matteo Bramuzzo1 , Davide Selvestrel1 ( 1 Trieste, 2 Aviano, 3 Cincinnati - USA)
P152
A new bioinformatic tool in the precision medicine perspective: preliminary evidence of its prognostic and predictive value
Luigi Cari, Francesca De Rosa, Graziella Migliorati, Giuseppe Nocentini, Carlo Riccardi (Perugia)
P153
Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and cHRFAM7a in macrophages: a possible link to the cholinergic antiinflammatory pathway
Simona Di Lascio, Silvia Cardani, Elisa Setten, Massimo Locati, Diego Fornasari, Roberta Benfante (Milan)
P154
Assessment of palytoxin irritation potential using an in vitro 3D epidermis mode
Marco Pelin, Silvio Sosa, Cristina Ponti, Federica Cavion, Chiara Florio, Aurelia Tubaro (Trieste)
P156
The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity
Michele Russo1 , Fiorentina Guida1 , Lorella Paparo1 , Giovanna Trinchese1 , Rosita Aitoro1 , Carmen Avagliano1 , Fabiana Napolitano1 , Antonella Fiordelisi1 , Valentina Mercurio1 , Valentina Sala2 , Mingchuan Li2 , Daniela Sorriento1 , Michele Ciccarelli
P157
Growth promoting effects of Methylmercury on thyroid cells in vitro
Valentina Maggisano, Stefania Bulotta, Marilena Celano, Jessica Maiuolo, Michelangelo Iannone, Diego Russo (Catanzaro)
P158
Toxicological investigation on a new topical hydroxypropil-β-cyclodextrin gel based formulation in male rat
Fatima Maqoud, Antonietta Mele, Nicola Zizzo, Rosa Scala, Nunzio Denora, Angela Assunta Lopedota, Domenico Tricarico (Bari)
P159
Role of mitochondrial Connexin43 in Trastuzumab-induced cardiotoxicit
Michela Pecoraro, Aldo Pinto, Ada Popolo (Salerno)
P160
Social defeat stress during early adolescence affects susceptibility to stressrelated disorders in adult rats
Enrico Marchetta, Giulia Federica Mancini, Marta Splendori, Patrizia Campolongo (Rome)
P161
Long-term effects of brief and repeated periods of brief social isolation stress during early adolescence
Giulia Federica Mancini, Enrico Marchetta, Marta Splendori, Marika Filosa, Patrizia Campolongo (Rome)
P162
P164
Effects of myo-inositol alone and in combination with seleno-L-methionine on cadmium-induced testicular damage in mic
Giovanni Pallio, Francesco Squadrito, Natasha Irrera, Domenico Puzzolo, Antonio Micali, Domenica Altavilla, Letteria Minutoli (Messina)
P166
Parental exposure to smoke and pregnancy outcomes
Emanuela Elisa Sorbara1 , Carmen Mannucci1 , Gioacchino Calapai1 , Fabrizio Calapai1 , Luigi Cardia1 , Angela Alibrandi1 , Alfredo Vannacci2 , Maria Carmela Lenti2 , Marcello Perone1 ( 1 Messina, 2 Florence)
P167
Beneficial effect of a peptide derived from gastrointestinal digestion of Buffalo (Bubalus bubalis) mozzarella cheese on intestinal inflammation
Ester Pagano1 , Gian Carlo Tenore1 , Stefania Lama1 , Daniela Vanacore1 , Salvatore Di Maro2 , Maria Maisto1 , Raffaele Capasso1 , Francesco Merlino1 , Paola Stiuso1 , Ettore Novellino1 , Francesca Borrelli1 ( 1 Naples, 2 Caserta)
P168
Evaluation of the mutagenic and antimutagenic activity of Ammodaucus leucotrichus and Perillaldehyde by flow cytometric analysis
Veronica Cocchi1 , Monia Lenzi1 , Carmela Fimognari2 , Patrizia Hrelia1 ( 1 Bologna, 2 Rimini)
P169
Anti-inflammatory and antioxidant activity of Aloe vera gel and Punica granatum: onconutraceutical potential in intestinal epithelial cells
Shara Francesca Rapa1 , Donato Cianciarulo1 , Fabrizio Merciai1 , Emanuela Salviati1 , Giacomo Pepe1 , Eduardo Sommella1 , Roberto Profili2 , Michele Manfra3 , Giuseppina Autore1 , Pietro Campiglia1 , Stefania Marzocco1 ( 1 Salerno, 2 Caserta, 3 Potenza)
P170
Effect of Plumericin on oxidative stress and barrier function in inflammatory bowel disease
Shara Francesca Rapa1 , Birgit Waltenberger2 , Rosanna Di Paola1 , Giuseppina Autore1 , Salvatore Cuzzocrea3 , Hermann Stuppner2 , Stefania Marzocco1 ( 1 Salerno, 2 Innsbruck - Austria, 3 Messina)
P171
Protective effects of a natural polyphenolic complex on lipid accumulation and vascular damage in oxidative stress conditions
Cristina Carresi, Miriam Scicchitano, Vincenzo Musolino, Saverio Nucera, Micaela Gliozzi, Francesca Bosco, Federica Scarano, Jessica Maiuolo, Roberta Macrì, Stefano Ruga, Francesca Noto, Maria Caterina Zito, Rocco Mollace, Beniamino Guerrieri, Lorenza Gu
P172
Effectiveness and tolerability of an overnight 4-week treatment with patch containing onion extract and allantoin for Cesarean section scars
Teresa Iannaccone1 , Graziamaria Corbi2 , Bianca Corrado1 , Luigi Giugliano1 , Antonella D’Apolito1 , Valentina Manzo1 , Maria Costantino1 , Maurizio Guida1 , Amelia Filippelli1 , Valeria Conti1 ( 1 Salerno, 2 Campobasso)
P173
Icariin protects H9C2 rat cardiomyoblasts from doxorubicin induced cardiotoxicity
Miriam Scicchitano, Cristina Carresi, Vincenzo Musolino, Jessica Maiuolo, Micaela Gliozzi, Francesca Bosco, Federica Scarano, Alessia Maretta, Saverio Nucera, Maria Caterina Zito, Roberta Macrì, Stefano Ruga, Lorenza Guarnieri, Francesca Noto, Martina Vi
P174
Posidonia oceanica (L.) Delile: antioxidant activity and nutraceutical content
Giorgio Giorgi, Agnese Manuguerra, Daniela Cerretani, Anna Ida Fiaschi, Laura Moltoni, Andrea Menchiari, Marco Rossi, Fausto Lorè, Simone Pannini, Lucia Micheli (Siena)
P175
Evaluation of the effect of omega-3 fatty acid administration on cardiovascular outcomes: a meta-analysis of randomized controlled trials
Marta Gazzotti1 , Manuela Casula1 , Elena Olmastroni1 , Alberto Zambon2 , Alberico Luigi Catapano1 ( 1 Milan, 2 Padua)
P176
Liposomes treatment antagonized dendritic spine loss and reduction of neurogenesis in hippocampus of chronically stressed rats
Cristina Mostallino1 , Francesca Biggio1 , Laura Boi1 , Valentina Locci1 , Rafaela Mostallino1 , Clara Porcedda1 , Gino Toffano2 , Giovanni Biggio1 ( 1 Cagliari, 2 Abano Terme)
P177
Relaxin-3 signalling in paraventricular nucleus of hypothalamus – pharmacological evidence for M-like potassium current activation
Alan Kania1 , Agata Szlaga1 , Patryk Sambak1 , Anna Gugula1 , Carlo Cifani2 , Andrew L. Gundlach3 , Anna Blasiak1 ( 1 Krakow - Poland, 2 Camerino, 3 Melbourne - Australia)
P178
An irreversible A3 adenosine receptor selective agonist ICBM inhibits N-type Ca2+ currents in rat dorsal root ganglion neurons
Federica Cherchi1 , Elisabetta Coppi1 , Irene Fusco1 , Mirko Scortichini2 , Kenneth A. Jacobson2 , Felicita Pedata1 , Anna Maria Pugliese1 ( 1 Florence, 2 Maryland - USA
P179
In vitro pharmacological characterization of transient receptor potential ankyrin 1 (TRPA1) agonists and antagonists
Chiara Sturaro1 , Chiara Ruzza1 , Delia Preti1 , Romina Nassini2 , Girolamo Calò1 , Pierangelo Geppetti2 ( 1 Ferrara, 2 Florence)
P180
A2A-D2 heteromerization on striatal astrocytes: evidence and modulation of glutamate release
Chiara Cervetto1 , Simone Pelassa1 , Diego Guidolin2 , Monica Averna1 , Rosa Bernardi3 , Guido Maura1 , Luigi F. Agnati4 , Manuela Marcoli1 ( 1 Genoa, 2 Padua, 3 Milan, 4 Modena)
P181
Photobiomodulation and glutamate release from cerebrocortical nerve terminals
Manuela Marcoli, Andrea Amaroli, Guido Maura, Stefano Benedicenti, Chiara Cervetto (Genoa)
P182
Effects of chronic administration of the adenosine A2B receptor agonist BAY60- 6583 on cerebral damage in a model of brain transient focal ischemia in the rat
Lisa Gaviano, Ilaria Dettori, Irene Bulli, Filippo Ugolini, Daniele Lana, Maria Grazia Giovannini, Felicita Pedata (Florence)
P183
Immunopharmacological Characterization Of Presynaptic Release-Regualting Ampa Auto Receptors In The Cortex Of Mice
Francesca Cisani, Matteo Vergassola, Guendalina Olivero, Cesare Usai, Anna Pittaluga (Genoa)
P184
mGLU1 receptor and GABAB receptor heterodimerization in cortical nerve terminals
Matteo Vergassola, Guendalina Olivero, Francesca Cisani, Alessandra Roggeri, Ilena Cervia, Cesare Usai, Simone Bossi, Aldamaria Puliti, Anna Pittaluga (Genoa)
P185
Nootropic effects of alpha-glyceryl-phosphoryl-ethanolamine in human hippocampal cells
Giorgina Mangano1 , Simona Daniele2 , Lucia Durando1 , Claudia Martini2 ( 1 S. Palomba-Pomezia, 2 Pisa)
P186
Palmitoylethanolamide reduces pain perception alterations in a central poststroke pain (CPSP) model
Rosmara Infantino, Monica Iannotta, Carmela Belardo, Livio Luongo, Ida Marabese, Vito de Novellis, Enza Palazzo, Flavia Ricciardi, Mariantonietta Scafuro, Sabatino Maione (Naples
P187
Oral cannabidiol prevents allodynia and neurological dysfunctions in a mouse model of mild traumatic brain injury
Carmela Belardo1 , Monica Iannotta1 , Serena Boccella1 , Rosamaria Cristina Rubino2 , Flavia Ricciardi1 , Rosmara Infantino1 , Gorizio Pieretti1 , Luigi Stella1 , Salvatore Paino1 , Ida Marabese1 , Rosa Maisto1 , Livio Luongo1 , Sabatino Maione1 , Frances
P188
Simultaneous activation of mu and delta opioid receptors reduces allodynia and astrocytic connexin 43 in an animal model of neuropathic pain
Nunzio Vicario, Lorella Pasquinucci, Federica Maria Spitale, Santina Chiechio, Rita Turnaturi, Filippo Caraci, Daniele Tibullo, Roberto Avola, Rosario Gulino, Rosalba Parenti, Carmela Parenti (Catania)
P190
Simultaneous activation of mu and delta opioid receptors reduces allodynia and astrocytic connexin 43 in an animal model of neuropathic pain
Nunzio Vicario, Lorella Pasquinucci, Federica Maria Spitale, Santina Chiechio, Rita Turnaturi, Filippo Caraci, Daniele Tibullo, Roberto Avola, Rosario Gulino, Rosalba Parenti, Carmela Parenti (Catania)
P191
A fluorescence-based assay to evaluate the activity of novel Kv7.2/Kv7.3 channel modulators
Piera Nappi1 , Francesco Miceli1 , Lidia Carotenuto1 , Carmine Ostacolo1 , Pietro Campiglia2 , Maurizio Taglialatela1 ( 1 Naples, 2 Salerno)
P191
Development and characterization of a new implantable biosensor for in vivo monitoring of brain glutamate
Andrea Bacciu, Paola Arrigo, Pier Andrea Serra, Gaia Rocchitta (Sassari)
P192
A methodology for adult astrocytes ex vivo study: looking for new therapeutic targets
Alessandra Toti, Laura Micheli, Elena Lucarini, Carmen Parisio, Lorenzo Di Cesare Mannelli, Carla Ghelardini (Florence)
P193
Safe and long-lasting transgene expression in the central nervous system using Herpes Simplex Virus -1 amplicon vectors
Silvia Zucchini1 , Marie Soukupova1 , Pascal Trempat2 , Coline PerrierBiollay2 , Selene Ingusci1 , Hervè Berthommé2 , Michele Simonato1 ( 1 Ferrara, 2 Villeurbanne - France)
P194
Generation and characterization of cell lines stably expressing different isoforms of KCNQ potassium channels suitable for drug screening
Isabella Coletta, Barbara Garofalo, Rosella Ombrato, Claudio Milanese, Francesco Paolo Di Giorgio, Serena Tongiani(Rome)
P195
Formyl peptide receptor 1 signalling in acute inflammation and neural differentiation induced by traumetic brain injury
Roberta Fusco1 , Maria Scuto2 , Enrico Gugliandolo1 , Marika Cordaro1 , Ramona D’Amico1 , Rosalba Siracusa1 , Alessio Filippo Peritore1 , Daniela Impellizzeri1 , Rosalia Crupi1 , Salvatore Cuzzocrea1 , Rosanna Di Paola1 ( 1 Messina, 2 Catania)
P196
Deficiency of serotonin at central or peripheral level alters neuroplastic and epigenetic mechanisms in adult rat
Giulia Sbrini1 , Paola Brivio1 , Natalia Alenina2 , Judith Homberg3 , Francesca Calabrese1 ( 1 Milan, 2 Berlin - Germany, 3 Nijmegen - The Netherlands)
P197
Brain histamine is essential for long-term but not short-term social memory
Barbara Rani1 , Bruna Silva-Marques2 , Patrizio Blandina1 , Maria Beatrice Passani1 , Rob Leurs3 , Gustavo Provensi1 ( 1 Florence, 2 Sao Carlos - Brazil, 3 Amsterdam - The Netherlands)
P198
Prokineticins induce the upregulation of histone demethylase KDM5C and KDM6A in bortezomib-induced peripheral neuropathy in mice
Laura Rullo1 , Francesca Felicia Caputi1 , Serena Stamatakos1 , Silvia Franchi2 , Giorgia Moschetti2 , Sanzio Candeletti1 , Paola Sacerdote2 , Patrizia Romualdi1 ( 1 Bologna, 2 Milan)
P200
Pharmacological restoration of autophagic flux in neuronal cultures protects from toxicity of prion protein fragment 90-231
Tullio Florio, Stefano Thellung, Alessandro Corsaro, Federica Barbieri, Martina Zambito, Katia Cortese (Genoa)
P201
New insights into the molecular mechanisms of the vardenafil-induced production of amyloid-beta
Ernesto Fedele, Francesca Caudano, Giulia Montalto, Mario Passalacqua, Roberta Ricciarelli (Genoa)
P202
Adult neural progenitor cells as new tool to study hypothalamic neurogenesis
Heather Bondi, Valeria Bortolotto, Alexia Car, Pier Luigi Canonico, Mariagrazia Grilli (Novara
P203
Retinal miRNA profile and electroretinography in dysbindin-1 null mutant albino mice: implications in Hermansky-Pudlak syndrome 7
Giovanni Luca Romano1 , Chiara Bianca Maria Platania2 , Gian Marco Leggio2 , Sebastiano Alfio Torrisi2 , Salvatore Salomone2 , Michele Purrello2 , Marco Ragusa2 , Cristina Barbagallo2 , Federica Conti2 , Rosa Mastrogiacomo3 , Francesca Managò3 , Maurizio
P204
Characterization of new users of PCSK9 inhibitors in Tuscany: a drug utilization study based on regional administrative dat
Carlo Piccinni1 , Ippazio Cosimo Antonazzo2 , Aldo Pietro Maggioni1 , Antonella Pedrini1 , Silvia Calabria1 , Giulia Ronconi1 , Letizia Dondi1 , Nello Martini1 , Giuseppe Roberto2 , Tiziana Sampietro3 , Francesco Sbrana3 , Beatrice Dal Pino3 , Federico Bi
P205
Current use of sedative drugs in paediatric intensive care units: a market evaluation of clonidine use and its economic impact
Fedele Bonifazi1 , Mirella Corio1 , Emilio Chiarolla1 , Viviana Giannuzzi1 , Annalisa Landi1 , Elisabetta Graps1 , Gabriele Ahne2 , Manuel Baarslag3 , Nicola Laforgia1 , Antje Neubert2 , Paula Pokorna4 , Alessandra Simonetti5 , Irmgard Toni2 , Maxi Torau2
P206
Linking administrative and hospital-pharmacy data to study drug utilization, survival and adverse infectious events in patients treated with rituximab at the University Hospital of Siena, Italy
Andrea Spini1 , Claudia Bartolini2 , Valentino Moscatelli1 , Alessandro Barchielli2 , Davide Paoletti1 , Silvano Giorgi1 , Alberto Fabbri1 , Monica Bocchia1 , Sandra Donnini1 , Rosa Gini2 , Marina Ziche1 , Giuseppe Roberto2 ( 1 Siena, 2 Florence)
P207
Linking regional administrative healthcare data with the pathology registry of the University Hospital of Siena (Italy) to describe treatment patterns of patients with non-small-cell lung cancer
Andrea Spini1 , Giuseppe Roberto2 , Cristiana Bellan1 , Alessandra Pascucci1 , Pietro Rosellini1 , Adele Caldarella2 , Alessandro Barchielli2 , Edoardo Francini3 , Sandra Donnini1 , Folco Furiesi1 , Lorenzo Leoncini1 , Silvano Giorgi1 , Claudia Bartolini2
P208
Analysis of persistence to the treatment among antidepressants users in Tuscany: a large regional drug-utilization study
Ippazio Cosimo Antonazzo1 , Giuseppe Roberto1 , Elisabetta Poluzzi2 , Rosa Gini1 ( 1 Florence, 2 Bologna)
P209
Pharmacological interventions for the prevention of foetal growth restriction: systematic review and network meta-analysis
Alessandra Bettiol1 , Niccolò Lombardi1 , Giada Crescioli1 , Laura Avagliano2 , Alessandro Mugelli1 , Claudia Ravaldi3 , Alfredo Vannacci3 ( 1 Florence, 2 Milan, 3 Prato)
P210
Evaluation of the appropriateness of use, effectiveness and safety of the different antidiabetic drugs in clinical practice: a population-based study in Southern Italy
Salvatore Crisafulli1 , Ylenia Ingrasciotta1 , Valentina Ientile1 , Maria Paola Bertuccio1 , Angela Alibrandi1 , Maurizio Pastorello2 , Ilaria Uomo2 , Salvatore Scondotto2 , Alessandro Scorsone2 , Vincenzo Provenzano2 , Gianluca Trifirò1 ( 1 Messina, 2 P
P211
Time to treatment intensification in patients on dual pharmacotherapy for type 2 diabetes: metformin+dipeptidyl peptidase inhibitor versus metformin+sulphonilura
Giuseppe Roberto1 , Francesco Barone-Adesi2 , Valeria Pizzimenti3 , Valentina Ientile3 , Claudia Bartolini1 , Corrado Magnani2 , Marina Maggini4 , Roberto Da Cas4 , Stefania Spila-Alegiani4 , Carmen Ferrajolo5 , Paolo Francesconi1 , Gianluca Trifirò3 , E
P212
Cumulative exposure to bisphosphonates and incidence of cardiovascular and cerebrovascular events: a population-based cohort study
Manuela Casula, Elena Olmastroni, Federica Galimberti, Elena Tragni, Giovanni Corrao, Lorenza Scotti, Alberico L. Catapano (Milan)
P213
Convergent sequencing and microarray data analyses suggest the involvement of miRNAs and target mRNAs in lithium response in bipolar disorder
Alessio Squassina1 , Claudia Pisanu1 , Eleni Merkouri Papadima1 , Carla Melis1 , Stefano Calza2 , Annalisa Loizedda3 , Nicola Orrù1 , Giovanni Severino1 , Raffaella Ardau1 , Caterina Chillotti1 , Sandro Orrù1 , Carlo Carcassi1 , Maria Del Zompo1 ( 1 Cag
P214
Differences in leukocyte telomere length between bipolar disorder patients and non-psychiatric controls are influenced by lithium treatment
Alessio Squassina1 , Claudia Pisanu1 , Donatella Congiu1 , Giovanni Severino1 , Alberto Bocchetta1 , Raffaella Ardau1 , Zoi Kordou2 , Theano Stamopoulou2 , Evangelia Eirini Tsermpini2 , George P. Patrinos2 , Caterina Chillotti1 , Maria Del Zompo1 ( 1 Cagl
P215
Development and validation of LC-MS/MS method for sorafenib, regorafenib and their active metabolites in hepatocellular carcinoma patients
Martina Zanchetta, Valentina Iacuzzi, Bianca Posocco, Elena Marangon, Ariana Soledad Poetto, Mauro Buzzo, Sara Gagno, Giuseppe Toffoli (Aviano)
P216
Role of intestinal microbiota in mediating the effects of thiopurines
Martina Franzin1 , Marianna Lucafò2 , Cristina Lagatolla1 , Marco Pelin1 , Gabriele Stocco1 , Giuliana Decorti1 ( 1 Trieste, 2 Aviano)
P217
Anti-tumor necrosis factor mechanism of action: what is the role of CD69 in infliximab response?
Debora Curci1 , Marianna Lucafò2 , Elisa Piscianz1 , Matteo Bramuzzo1 , Gabriele Stocco1 , Giuliana Decorti1 ( 1 Trieste, 2 Aviano)
P218
Induced pluripotent stem cells as an innovative model for pharmacological studies in patients with Aicardi-Goutières Syndrome
Federica Cavion1 , Elena Genova1 , Marianna Lucafò2 , Marco Pelin1 , Alessandra Tesser1 , Elisa Piscianz1 , Gaetana Lanzi3 , Stefania Masneri3 , Rosalba Ferraro3 , Giuliana Decorti1 , Alberto Tommasini1 , Silvia Giliani3 , Gabriele Stocco1 ( 1 Trieste, 2
P219
Investigations on the molecular mechanism of PACSIN2 in the regulation of TPMT activity and autophagy
Giulia Zudeh, Raffaella Franca, Gabriele Stocco, Giuliana Decorti (Trieste)
P220
SIRT1 activity and different heart failure phenotypes
Valentina Manzo1 , Valeria Conti1 , Graziamaria Corbi2 , Michele Ciccarelli1 , Maria Vincenza Polito1 , Teresa Iannaccone1 , Martina Torsiello1 , Emanuela De Bellis1 , Maria Costantino1 , Federica D’Auria1 , Gennaro Vitulano1 , Federico Piscione1 , Amel
P221
Mechanisms of resistance to a PI3K Inhibitor in Gastrointestinal Stromal Tumors: an omic approach aimed to identify novel druggable targets
Gloria Ravegnini1 , Federica Zanotti1 , Giulia Sammarini1 , Sebastian Moran2 , Giovanni Calice3 , Valentina Indio1 , Milena Urbini1 , Annalisa Astolfi1 , Maria Pantaleo1 , Patrizia Hrelia1 , Sabrina Angelini1 (1 Bologna, 2 Barcelona - Spain, 3 Rionero in
P222
Characterization of novel Bartter syndrome mutations in CLCNKB and chaperone efficacy of ClC-Kb ligands towards a personalized medicine
Dalila Sahbani1 , Bice Strumbo2 , Silvana Tedeschi2 , Giuseppe Procino1 , Giovanni Montini2 , Diana Conte1 , Paola Imbrici1 , Antonella Liantonio1 ( 1 Bari,2 Milan)
P223
transgenic mice mirroring the human Cantu Syndrome
Fatima Maqoud1 , Rosa Scala1 , Antonietta Mele1 , Francesca Sanarica1 , Conor McClenaghan2 , Theresa M. Harter2 , Colin G. Nichols2 , Domenico Tricarico1 ( 1 Bari, 2 Saint Louis - USA)
P224
Rare diseases and clinical research: the 10-years experience of ASL Lecce Ethics Committee
Maria Rita De Giorgio, Cinzia Morciano, Stefania Di Noia, Diana Conte (Lecce)
P227
Pharmacological chaperone to treat myotonia congenita caused by traffickingdefective ClC-1 chloride channel mutants: proof-of-concept with niflumic acid
Concetta Altamura1 , Dalila Sahbani1 , Elena Conte1 , Francesco Girolamo1 , Sabrina Lucchiari2 , Giacomo P. Comi2 , Mauro Lo Monaco3 , Evgeniya Ivanova4 , Maria Rosaria Carratù1 , Diana Conte Camerino1 , Paola Imbrici1 , Jean-François Desaphy1 ( 1 Bari,
P228
Development of new benzothiazolamines to enhance use-dependent inhibition of voltage-gated sodium channels
Concetta Altamura, Alessandro Farinato, Sabata Pierno, Nancy Tarantino, Maria Maddalena Cavalluzzi, Giovanni Lentini, Maria Rosaria Carratù, JeanFrançois Desaphy (Bari)
P229
Metabolic and epigenetic regulators as pathology and therapy biomarkers in preclinical research on Duchenne Muscular Dystrophy: new insights into the gene and protein expression profile in murine models
Brigida Boccanegra1 , Paola Mantuano1 , Francesca Sanarica1 , Gianluca Fossati2 , Monica Forino2 , Valeria Spadotto2 , Christian Steinkühler2 , Annamaria De Luca1 ( 1 Bari, 2 Milan)
P230
Safinamide repositioning in non dystrophic myotonias: a new therapeutic opportunity for this rare disease
Jean-François Desaphy1 , Michela De Bellis1 , Alessandro Farinato1 , Concetta Altamura1 , Paola Imbrici1 , Carla Caccia2 , Elsa Melloni2 , Gloria Padoani2 , Silvia Vailati2 , Charlotte Keywood2 , Diana Conte1 , Sabata Pierno1 ( 1 Bari, 2 Bresso)
P231
Vaccines safety in children and in general population: a pharmacovigilance study on adverse events following immunization in Italy
Niccolò Lombardi1 , Giada Crescioli1 , Alessandra Bettiol1 , Marco Tuccori2 , Marco Rossi3 , Roberto Bonaiuti1 , Claudia Ravaldi1 , Miriam Levi1 , Silvia Ricci1 , Francesca Lippi1 , Martina Del Lungo1 , Linda Giovannetti1 , Valentina Borsi1 , Maria Parri
P232
Surveillance of adverse events following immunization related to human papillomavirus vaccines: 12 years of vaccinovigilance in Southern Italy
Cristina Scavone, Cristina Di Mauro, Simona Brusco, Michele Bertini, Gabriella di Mauro, Concetta Rafaniello, Liberata Sportiello, Annalisa Capuano (Naples)
P233
Adverse drug reactions during hepatitis C treatment with direct-acting antivirals: The role of medication errors, their impact on treatment discontinuation and their preventability. New insights from the Campania Region (Italy) spontaneous reporting syste
Maurizio Sessa1 , Francesca Futura Bernardi1 , Andrea Vitale2 , Beniamino Schiavone2 , Giulia Gritti1 , Annamaria Mascolo1 , Michele Bertini1 , Cristina Scavone1 , Liberata Sportiello1 , Annalisa Capuano (1 Naples, 2 Castel Volturno)
P234
The usefulness of listening social media for pharmacovigilance purposes
Irma Convertino, Sara Ferraro, Luca Leonardi, Corrado Blandizzi, Marco Tuccori (Pisa)
P235
Allopurinol-induced severe cutaneous adverse drug reactions: an analysis of spontaneous reporting system in Southern Italy
Cristina Di Mauro, Cristina Scavone, Rosanna Ruggiero, Francesca Futura Bernardi, Ugo Trama, Maria Luisa Aiezza, Concetta Rafaniello, Annalisa Capuano (Naples)
P236
P238
Efficacy of methadone in drug use disorder in chronic non-cancer pain
Daniele Innocenti, Guido Mannioni, Matilde Degano, Cecilia Lanzi, Brunella Occupati (Florence)
P239
nduced pluripotent stem cells-derived neurons as disease models to investigate the molecular pathogenesis and pharmacological responses in geneticallydetermined epileptic channelopathies
Elena Longobardi1 , Sebastien Moutton2 , Francesco Miceli1 , Giusy Laudati1 , Anna Lauritano1 , Rita Cicatiello1 , Lucio Nitsch1 , Maurizio Taglialatela1 ( 1 Naples, 2 Dijon - France)
P240
Vulnerability traits exhibited by MAO-A hypomorphic mice
Valeria Serra1 , Silvia Fanni1 , Claudia Sagheddu1 , Francesco Traccis1 , Paola Devoto1 , Roberto Frau1 , Miriam Melis1 , Marco Bortolato2 ( 1 Cagliari, 2 Salt Lake City - USA)
P242
Characterization of chloride channel 1 from birth to aging in rat fast and slow twitch muscles by the analysis of gene and protein expression, cellular localization and modulation by PKC
Elena Conte, Adriano Fonzino, Antonio Cibelli, Paola Imbrici, Grazia Paola Nicchia, Sabata Pierno, Annamaria De Luca, Giulia Maria Camerino (Bari)
P243
Role of RACK1 mediated signalling in breast cancer cells migration/metastasis
Erica Buoso1 , Melania Ronfani1 , Mirko Masi1 , Marilisa Galasso2 , Denise Ventura1 , Emanuela Corsini3 , Marco Racchi1 ( 1 Pavia, 2 Verona, 3 Milan)
P244
Homeobox transcription factors OTX1 and OTX2 Involvement in rat myenteric plexus plasticity after DNBS-induced colitis
Annalisa Bosi1 , Michela Bistoletti1 , Giovanni Micheloni1 , Elisabetta Moro2 , Andreina Baj1 , Francesca Crema2 , Giovanni Porta1 , Cristina Giaroni1 (1 Varese, 2 Pavia
P245
Delta-9-tetrahydrocannabinol and cannabidiol for the treatment of refractory pain in failed back surgery syndrome
Luigi Cardia, Epifanio Mondello, Domenico Quattrone, Giuseppe Bova, Alessia Barbagallo, Cristina Mondello, Carmen Mannucci, Fabrizio Calapai, Emanuela Elisa Sorbara, Vincenzo Arcoraci, Gioacchino Calapai (Messina)
P247
Medication Related Osteonecrosis of the Jaw: Melatonin functions and effects
Guido Lorenzini, Simone Pannini, Marco Rossi, Giorgio Giorgi (Siena)
P249
New insights into muscle atrophy: exploring the relationship between muscle and bone
Francesca Bosco1 , Vincenzo Musolino1 , Micaela Gliozzi1 , Miriam Scicchitano1 , Saverio Nucera1 , Federica Scarano1 , Cristina Rita Carresi1 , Jessica Maiuolo1 , Stefano Ruga1 , Maria Caterina Zito1 , Francesca Rita Noto1 , Martina Vitelli1 , Beniamino G
P250
Obesity is associated with in vivo platelet activation and impaired responsiveness to once-daily, low-dose aspirin
Giovanna Petrucci1 , Francesco Zaccardi2 , Alberto Giaretta3 , Viviana Cavalca4 , Carmine Cardillo1 , Dario Pitocco1 , Benedetta Porro4 , Francesca Schinsari1 , Francesca Pagliaccia1 , Gianna Toffolo3 , Elena Tremoli4 , Bianca Rocca1 ( 1 Rome, 2 Leicester
P251
Blood-retinal barrier protection against high glucose damage: the role of P2X7 receptor
Claudia Giuseppina Fresta, Chiara Bianca Maria Platania, Francesca Lazzara, Annamaria Fidilio, Giovanni Giurdanella, Federica Conti, Gian Marco Leggio, Salvatore Salomone, Filippo Drago, Claudio Bucolo (Catania)
P253
Atropine repositioning in clinical research
Maddalena Toma1 , Rosa Conte1 , Antonella Didio1 , Fedele Bonifazi1 , Viviana Giannuzzi1 , Annegret Dahlmann Noor2 , Oscar Della Pasqua2 , Catherine Tuleu2 , Adriana Ceci1 ( 1 Bari, 2 London - United Kingdom)
P254
Effects of ototoxic drugs on a new in vitro model of stria vascularis
Federica Conti, Giovanni Giurdanella, Florinda Gennuso, Claudio Bucolo, Filippo Drago, Salvatore Salomone (Catania)
P255
Small molecules to treat diabetic retinopathy: in silico and in vitro approaches for discovery of HuR inhibitors
Chiara Bianca Maria Platania1, Nicoletta Marchesi2, Valeria Pittalà1, MartinaCristaldi1, Melania Oliveri1, Daniela Anfuso1, Gabriella Lupo1, Filippo Drago1,Alessia Pascale2, Claudio Bucolo1 (1Catania, 2Pavia
P256
Artocarpus tonkinensis protects mice against collagen-induced arthritis and decreases Th17 cell function
Sabrina Adorisio, Isabella Muscari, Lorenza Cannarile, Emira Ayroldi, Carlo Riccardi, Domenico V. Delfino (Perugia)
P260
Chemical profiling and pharmaco-toxicological activity of Origanum sipyleum extracts: Exploring for novel sources for potential therapeutic agents
Gokhan Zengin1 , Lucia Recinella2 , Annalisa Chiavaroli2 , Sheila Leone2 , Luigi Brunetti2 , Giustino Orlando2 , Claudio Ferrante2 ( Konya - Turkey, 2 Chieti)
P261
Chemical profiles and pharmacological activity of two Anthemis species: Anthemis tinctoria var. pallida and A. cretica subsp. tenuiloba
Claudio Ferrante, Gokhan Zengin, Lucia Recinella, Annalisa Chiavaroli, Sheila Leone, Luigi Brunetti, Luigi Menghini, Giustino Orlando (Chieti)
P262
Protective and restorative effect of nutrients and phytochemicals
Walter Milano1 , Anna Capasso2 ( 1 Naples, 2 Salerno)
P263
Spermidine is a novel modulator of Src Kinase-mediated signaling pathway in dendritic cells
Giada Mondanelli, Elisa Proietti, Marco Gargaro, Ciriana Orabona, Claudia Volpi (Perugia)
P264
SUMO proteins: guardians of immune system
Isabella Muscari, Sabrina Adorisio, Carlo Riccardi, Domenico Delfino (Perugia)
P265
Cardiovascular alterations in eating disorders
Walter Milano1 , Anna Capasso2 ( 1 Naples, 2 Salerno)
P266
Sex difference in adenosine diphosphate-induced rat platelet aggregation: a role for the ectonucleotide triphosphate diphosphohydrolase 1 enzyme
Elisabetta Caiazzo, Rossella Bilancia, Antonietta Rossi, Armando Ialenti, Carla Cicala (Naples)
P267
Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: an insight into nutraceutical development
Miriam Durante1 , Gabriele Carullo2 , Fabio Sciubba3 , Donatella Restuccia2 , Umile Gianfranco Spizzirri2 , Amer Ahmed1 , Maria Enrica Di Cocco3 , Francesca Aiello2 , Fabio Fusi1 , Simona Saponara1 ( 1 Siena, 2 Cosenza, 3 Rome)
P268
Association between apolipoprotein B lowering and cardiovar risk reduction: a meta-analysis of randomized controlled trials
Federica Galimberti1 , Alberico L. Catapano1 , Arjen J. Cupido2 , Julius L. Katzmann3 , Anthony C. Keech4 , Allan D. Sniderman5 , Brian A. Ference6 ( 1 Milan, 2 Amsterdam - The Netherlands, 3 Leipzig - Germany, 4 Sidney - Australia, 5 Montreal - Canada, 6
P269
Perivascular adipose tissue modulation of quercetin vasorelaxant effects on rat aorta rings
Amer Ahmed, Stefano Tagliafierro, Silvia Conti, Fabio Fusi, Massimo Valoti (Siena)
P271
Impact of dipeptidyl-peptidase IV inhibitors as add-on therapy to metformin on circulating oxidative stress biomarkers and microRNAs in patients with type 2 diabetes: an observational study
Elisabetta Bigagli, Cristina Luceri, Ilaria Dicembrini, Edoardo Mannucci, Lorenzo Tatti, Lisa Giovannelli, Maura Lodovici (Florence)
P272
3-iodothyronamine(T1AM) reduces brown adipose tissue differentiation and function
Manuela Gencarelli, Costanza Mazzantini, Annunziatina Laurino, Laura Raimondi (Florence)
P273
Indoxyl Sulfate affects immune response and intestinal homeostasis in mice regulating inflammatory response and oxidative stress
Shara Francesca Rapa1 , Donato Cianciarulo1 , Ada Popolo1 , Giuseppina Autore1 , Valentina Iovane1 , Biagio Raffaele Di Iorio2 , Fuyu Nishijima3 , Orlando Paciello4 , Aldo Pinto1 , Stefania Marzocco1 ( 1 Salerno, 2 Avellino, 3 Tokyo - Japan, 4 Naples)
P274
N-acetylserotonin exerts neuroprotective effects enhancing IDO1 catalytic activity
Eleonora Panfili1 , Claudia Volpi1 , Giada Mondanelli1 , Laura Santambrogio2 , Ursula Grohmann1 ( 1 Perugia, 2 New York - USA)
P275
The orphan nuclear receptor NR2F6 as a novel regulator of immune responses
Eleonora Padiglioni, Giorgia Manni, Marco Gargaro, Francesca De Franco, Francesco Greco, Antonio Macchiarulo, Roberto Pellicciari, Francesca Fallarino (Perugia)
P276
Cyp1a1 deficiency confers immunoregulatory functions to type 2 dendritic cells
Dario Nardi1 , Marco Gargaro1 , Carsten Schmidt-Weber2 , Caspar Ohnmacht2 , Renske Johanna Jong2 , Francesca Fallarino1 ( 1 Perugia - Italy, 2 Munich - Germany)
P277
High-throughput mirnome and transcriptome profiling in thalidomide sensitive pediatric inflammatory bowel disease patients
Marianna Lucafò1 , Matteo Bramuzzo2 , Letizia Pugnetti2 , Marco Gerdol2 , Samuele Greco2 , Monica Paci3 , Debora Curci2 , Sara Renzo3 , Paolo Lionetti3 , Alberto Pallavicini2 , Giuliana Decorti2 , Gabriele Stocco2 ( 1 Aviano, 2 Trieste, 3 Florence)
P278
Targets of dimethyl fumarate: a novel predictive method based on concepts of network theory and machine learning
Arianna Carolina Rosa, Elisa Benetti, Jessica Audisio, Gianluca Miglio (Turin)
P279
Pharmacological characterization of new NLRP3 inflammasome inhibitors
Valentina Boscaro, Simone Gastaldi, Marco Marino, Marta Giorgis, Elisabetta Marini, Massimo Bertinaria, Margherita Gallicchio (Turin)
P280
Beta-caryophyllene mitigates collagen antibody induced arthritis in mice through a cross-talk between the cannabinoid 2 and peroxisome proliferatoractivated receptor gamma receptors
Natasha Irrera, Angela D’Ascola, Alessandra Bitto, Giovanni Pallio, Federica Mannino, Letteria Minutoli, Francesco Squadrito, Domenica Altavilla (Messina)
P281
Effects of lipoxygenase inhibitors on eicosanoid production in human whole blood and isolated platelets in vitro
Rosa Fullone, Melania Dovizio, Stefania Tacconelli, Mirko Zucchelli, Patrizia Ballerini, Paola Patrignani (Chieti)
P282
AMPA receptor-mediated neurotoxicity in an in vitro model of ethanol dependence and withdrawal
Elisabetta Gerace1 , Daniele Lana1 , Daniela Iezzi1 , Lucia Caffino2 , Daniela Buonvicino1 , Alice Ilari3 , Alessio Masi3 , Carmen Carbone1 , Maria Grazia Giovannini1 , Fabio Fumagalli2 , Domenico E. Pellegrini-Giampietro1 , Guido Mannaioni1 ( 1 Florence,
P283
Co-mutagenic and pro-oxidant effects of Vitamin E promotes DNA damage and cell transformation in prostate
Fabio Vivarelli1 , Donatella Canistro1 , Silvia Cirillo1 , Alessio Papi1 , Enzo Spisni1 , Andrea Vornoli1 , Clara Maria Della Croce2 , Vincenzo Longo2 , Paola Franchi1 , Sandra Filippi1 , Marco Lucarini1 , Cristina Zanzi1 , Francesca Rotondo1 , Antonello
P284
Environmental and biological monitoring of formaldehyde inside a hospital setting: a combined approach for risk assessment evaluation and management
Bruno Charlier, Albino Coglianese, Oriana Motta, Franco De Caro, Viviana Izzo, Fabrizio Dal Piaz, Amelia Filippelli (Salerno)
P285
Enteric glia activation by HIV-1 Tat-induced diarrhea drives a glial inflammatory reaction to the central nervous system associated with a significant cognitive decline
Luisa Seguella1 , Mirella Pesce1 , Riccardo Capuano1 , Giovanni Sarnelli2 , Marcella Pesce2 , Giuseppe Esposito1 ( 1 Rome, 2 Naples)
P286
Role of adenosine A2B receptors in the modulation of enteric glial cell activity in a model of obesity
Vanessa D’Antongiovanni1 , Matteo Fornai1 , Carolina Pellegrini1 , Laura Benvenuti1 , Alma Di Carlo1 , Valentina Caputi2 , Maria Cecilia Giron2 , Nunzia Bernardini1 , Chiara Ippolito1 , Cristina Segnani1 , Rocchina Colucci2 , Corrado Blandizzi1 , Luca A
P287
Role of enteric glia in the development of intestinal dysmotility associated with high fat diet in mice
Laura Benvenuti1 , Luca Antonioli1 , Rocchina Colucci2 , Carolina Pellegrini1 , Vanessa D’Antongiovanni1 , Alma Di Carlo1 , Valentina Caputi2 , Maria Cecilia Giron2 , Corrado Blandizzi1 , Matteo Fornai1 ( 1 Pisa, 2 Padua)
P288
Colonic mucosal levels of µ-opioid receptor, β-endorphin and cannabinoid receptor-2 are increased in irritable bowel syndrome
Giovanni Dothel1 , Wendy Shih2 , Maria Raffaella Barbaro1 , Cesare Cremon1 , Vincenzo Stanghellini1 , Fabrizio De Ponti1 , Emeran Anton Mayer2 , Lin Chang2 , Giovanni Barbara1 , Catia Sternini2 ( 1 Bologna, 2 Los Angeles - USA)
P289
Hyaluronan involvement in neuromuscular adaptation to intestinal ischemia/ reperfusion injury
Michela Bistoletti1 ,Ilaria Caon1 , Annalisa Bosi1 , Elisabetta Moro2 , Manuela Viola1 , Andreina Baj1 , Davide Vigetti1 , Francesca Crema2 , Alberto Passi1 , Cristina Giaroni1 ( 1 Varese, 2 Pavia)
P290
Neurotoxicity of high doses intrathecal baclofen in a pediatric patient
Giulia Scaravaggi1 , Azzurra Schicchi1 , Davide Lonati1 , Marco Cirronis1 , Francesca Maida1 , Sara Olivotto2 , Silvia Masnada2 , Rossella Gottardo3 , Nadia M. Porpiglia3 , Franco Tagliaro3 , Eleonora Buscaglia1 , Carlo A. Locatelli1 ( 1 Pavia, 2 Milan, 3
P291
Oxycodone abuse during pain-relief prescription: an unusual but important cause
Marco Cirronis, Davide Lonati, Elena Brambilla, Azzurra Schicchi, Giulia Scaravaggi, Marta Crevani, Piero Papa (Pavia)
P292
Zidovudine overdose due to therapeutic error in newborn
Eleonora Buscaglia1 , Maria Di Primo1 , Giulia Scaravaggi1 , Azzurra Schicchi1 , Valeria M. Petrolini1 , Marco Cirronis1 , Marta Crevani1 , Francesca Maida1 , Giuseppe Bruglieri2 , Carlo A. Locatelli1 ( 1 Pavia, 2 Pesaro)
P293
Mitomycin C adverse reaction after intravesical instillation
Francesca Maida, Valeria M. Petrolini, Marco Cirronis, Elena Brambilla, Eleonora Buscaglia, Maria Di Primo, Marta Crevani, Carlo A. Locatelli (Pavia)
P294
Acute effects in mice of synthetic cannabinoids (JWH-018 / 5F-PB-22) on neuronal electrophysiological responses
Mario Barbieri1 , Sabrine Bilel1 , Micaela Tirri1 , Raffaella Arfè2 , Giovanni Serpelloni3 , Margherita Neri1 , Matteo Marti1 ( 1 Ferrara, 2 Rome, 3 Verona)
P295
Histopathologic changes in liver and small intestine induced by ketorolac and ketogal repeated oral treatment in mice
Carmen De Caro1 , Roberto Russo2 , Monica Tizzano2 , Salvatore Magliocca3 , Carmen Avagliano2 , Claudia Cristiano2 , Giovanna La Rana2 , Bice Avallone2 , Federica Sodano4 Stefania Albrizio2 , Antonio Calignano2 , Maria Grazia Rimoli2 ( 1 Catanzaro, 2 Napl
P296
Appropriateness of access to innovative drugs in non-small cell lung cancer (NSCLC): the FOIFVG (Innovative Oncology Drugs Friuli Venezia Giulia) project
Marilena Marinelli1 , Chiara Zanusso1 , Lucia Scarabel1 , Alessandra Bearz1 , Alessandro Del Conte1 , Michele Spina1 , Francesco Mazza2 , Paolo Schincariol3 , Paolo Sandri4 , Mariagrazia Michieli1 , Marina Tosolini5 , Stefano Visintin6 , Maria Grazia Tron
P297
Use and expenditure of biological medicines at the University Hospital of Catania
Daniela Cristina Vitale, Lucia Gozzo, Laura Longo, Filippo Drago (Catania)
P298
Effect of theranostic phospholipidic SrCl2/SrI2 and β-D-fructopyranose based nanoparticles on cell viability and uptake
Valentina Boscaro, Domenica Marabello, Paola Antoniotti, Paola Benzi, Alessandro Barge, Fabio Beccari, Carlo Canepa, Elena Peira, Margherita Gallicchio (Turin
P300
Effect of cetuximab-5-fluorouracil conjugates on the proliferation of colorectal cancer cells
Valentina Boscaro, Mirko Sacco, Pietro Aprà, Federico Picollo, Alessandro Barge, Margherita Gallicchio (Turin)
P301
Effects of new hydroxyazoles inhibitors of AKR1C3 on vitality of prostate and colorectal cancer cell lines
Valentina Boscaro, Donatella Boschi, Simonetta Oliaro-Bosso, Martina Daga, Marco Lolli, Agnese Chiara Pippione, Margherita Gallicchio (Turin)
P302
Effectiveness of RF22c, a selective 5-LO inhibitor, in pulmonary arterial hypertension treatment and innovative optimization of its delivery
Renata Esposito1 , Angela Liparulo1 , Giuseppe Spaziano1 , Nello Giugliano1 , A.C. Muñoz Ramirez2 , Annalisa Capuano1 , Rosanna Filosa1 , Carmelo Puglia3 , Bruno D’Agostino1 (1Naples, 2 Santiago de Chile - Chile, 3 Catania)
P303
Food addiction: a new form of dependence?
Walter Milano1 , Anna Capasso2 ( 1 Naples, 2 Salerno)
P304
Calcium mobilization and fibroblast proliferation: a platform to screen antifibrotic compounds in primary human fibroblasts
Francesca Murarolli, Prisca Martinelli, Rosaria Remelli, Martina Antolin (Verona)
P305
Effects of Hexarelin in a model of ARDS
Laura Rizzi1 , Vanessa Zambelli1 , Laura Molteni1 , Paolo Delvecchio1 , Elena Bresciani1 , Ramona Meanti1 , J.A. Fehrentz2 , J. Martinez2 , Giacomo Bellani1 , Vittorio Locatelli1 , Antonio Torsello1 (1 Milan, 2 Montpellier - France)
P306
A possible interaction between glucocorticoid-induced leucine zipper and histamine H4 receptor in counteracting pulmonary fibrosis in a bleomycininduced mouse model
Silvia Sgambellone1 , Laura Lucarini1 , Mariaconcetta Durante1 , Daniele Innocenti1 , Alessandro Pini1 , Stefano Bruscoli2 , Sara Flamini2 , Carlo Riccardi2 , Emanuela Masini1 ( 1 Florence, 2 Perugia)
P307
Angiotensin-II drives human satellite cells toward hypertrophy and myofibroblast trans-differentiation by two independent pathways: a basis to support the use of renin angiotensin system blockers in skeletal muscle wasting and fibrosis
Valentina Balducci, Manuela Gencarelli, Annunziatina Laurino, Costanza Mazzantini, Valentina Spinelli, Marco Ghionzoli, Alessandro Messineo, Alessandro Mugelli, Elisabetta Cerbai, Laura Raimondi, Laura Sartiani (Florence)
P308
P309
FARMAPRICE: development of a pharmacogenetic clinical decision support system and preliminary evaluation of its feasibility and usability in the clinical practice
Rossana Roncato1 , Lisa Dal Cin1 , Silvia Mezzalira1 , Francesco Comello1 , Elena De Mattia1 , Lorenzo Giollo2 , Simone D’Errico2 , Antonio Gulotta2 , Luca Emili3 , Vincenzo Carbone3 , Michela Guardascione1 , Luisa Foltran1 , Giuseppe Toffoli1 , Erika C
P310
The signalling pathways triggered by pulsed electromagnetic fields in the relief of hypoxia-induced neuronal cell death
Stefania Gessi1 , Stefania Merighi1 , Enrica Battistello1 , Luca Giacomelli1 , Fabrizio Vincenzi1 , Stefania Setti2 , Matteo Cadossi2 , Pier Andrea Borea1 , Ruggero Cadossi2 , Katia Varani2 ( 1 Ferrara, 2 Carpi)
P312
Characterization of signaling pathways enrolled by pulsed electromagnetic fields to produce anti-inflammatory effects in microglial cells
Stefania Merighi1 , Stefania Gessi1 , Enrica Battistello1 , Luca Giacomelli1 , Fabrizio Vincenzi1 , Stefania Setti2 , Matteo Cadossi2 , Pier Andrea Borea1 , Ruggero Cadossi2 , Katia Varani1 ( 1 Ferrara, 2 Carpi)
P313
Efficacy of a medical device containing xyloglucan on a mouse model of allergic rhinitis
Emanuela Esposito, Giovanna Casili, Marika Lanza, Michela Campolo, Alessia Filippone, Irene Paterniti, Salvatore Cuzzocrea (Messina)
P314
Synergistic effect of lenvatinib and vinorelbine combination in anaplastic thyroid cancer
Daniela Gentile, Paola Orlandi, Teresa Di Desidero, Guido Bocci, Marta Banchi (Pisa)
P315
Melanocortin receptor-4, a new therapeutic target of melanoma cells
Paola Orlandi1 , Daniela Gentile1 , Teresa Di Desidero1 , Francesca Vaglini1 , Carla Pardini1 , Cristina Viaggi1 , Marta Banchi1 , Federico Cucchiara1 , Alessandra Ottani2 , Daniela Giuliani2 , Michele Lai1 , Stefano Aringhieri1 , Marco Carli1 , Shiva Kol
P316
Angiogenesis-related circulating biomarkers and benefit from second-line treatment with paclitaxel and ramucirumab in advanced gastric cancer
Guido Bocci, Gianna Musettini, Paola Orlandi, Irene Pecora, Teresa Di Desidero, Daniela Gentile, Caterina Vivaldi, Marta Banchi, Giulia Pasquini, Federico Cucchiara, Francesca Salani, Silvia Catanese, Monica Lencioni, Alfredo Falcone (Pisa)
P317
Effect of pazopanib monotherapy versus combination with topotecan in anaplastic thyroid cancer
Effect of pazopanib monotherapy versus combination with topotecan in anaplastic thyroid cancer
P318
Melanocortin receptor 4 activity in melanoma cells: mechanism of action of the selective inhibitor ML00253764
Stefano Aringhieri, Marco Carli, Shiva Kolachalam, Francesca Vaglini, Carla Pardini, Cristina Viaggi, Paola Orlandi, Daniela Gentile, Federico Cucchiara, Guido Bocci, Marco Scarselli (Pisa)
P319
Graphene quantum dots conjugated with bortezomib analogues improve drug delivery and efficacy in an in vitro model of multiple myeloma
Alessandra Bitto, Federica Mannino, Giovanni Pallio, Natasha Irrera, Irene Gasparo, Robera Ettari, Salvatore Giofrè, Daniela Iannazzo, Alessandro Pistone, Alessandro Allegra, Domenica Altavilla, Francesco Squadrito (Messina)
P321
Cold atmospheric plasma as an innovative anticancer strategy: insight into its cellular and molecular impact on leukemia models
Eleonora Turrini1 , Emanuele Simoncelli2 , Romolo Laurita2 , Augusto Stancampiano2 , Elena Catanzaro1 , Cinzia Calcabrini1 , Giovanni Carulli3 , Martina Rousseau3 , Matteo Gherardi2 , Francesca Maffei1 , Veronica Cocchi2 , Monia Lenzi2 , Valentina Pellici
P322
Nanoemulsion based chemotherapy for melanoma
Benedetta Ferrara1 , Luigi Battaglia2 , Chiara Monge2 , Loredana Serpe2 , Katia Martina2 , Silvia Mioletti2 , Nausicaa Clemente3 , Chiara Dianzani2 ( 1 Creteil - France, 2 Turin, 3 Novara)
P323
In vitro effects of Berberine on pediatric low grade astrocytoma cells: a pilot study toward preclinical evaluations
Fabio Gabriele, Carolina Martinelli, Giorgia Bresciani, Vanessa Pipoli, Sergio Comincini (Pavia
P324
Antitumor effects of curcumin analogs in triple negative breast cancer (TNBC) cell lines
Paola Poma1 , Monica Notarbartolo1 , Anna Barattucci2 , Tania Salerno2 , Paola Maria Bonaccorsi2 , Manuela Labbozzetta1 ( 1 Palermo, 2 Messina)
P325
Effect of Lactobacillus farciminis supplementation in preventing LPS-induced hippocampal neuroinflammation, in mice
Carla Petrella1 , Georgios Strimpakos1 , Francesca de Santa1 , Marco Fiore1 , Stefano Farioli Vecchioli1 , Diego Mora2 , Stefania Arioli2 ( 1 Rome, 2 Milan)
P327
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy
Carmen De Caro1 , Luigi Francesco Iannone1 , Valentina Nesci1 , Paolo Mainardi2 , Martina Tallarico1 , Giovambattista De Sarro1 , Emilio Russo1 , Rita Citraro1 ( 1 Catanzaro, 2 Genoa)
P328
Gut and brain speech: gain in bifidobacteria alters the hippocampal GABAergic plasticity in healthy male rats
Francesca Biggio, Maria Cristina Mostallino, Giuseppe Talani, ValentinaLocci, Laura Boi, Raffaela Mostallino, Clara Porcedda, Enrico Sanna,Giovanni Biggio (Cagliari)
P329
Gut-brain axis: fecal microbiota transplantation decreases spontaneous spikewave discharges in WAG/Rij rats, a model of absence epilepsy
Martina Tallarico1 , Rita Citraro1 , Carmen De Caro1 , Antonio Leo1 , Antonio Calignano2 , Giovambattista De Sarro1 , Emilio Russo1 ( 1 Catanzaro, 2 Naples)
P330
Targeting sphingosine 1-phosphate receptors in autism spectrum disorders: focus on gut and brain
Rosa Luisa Potenza, Monica Boirivant, Roberta De Simone, Monica Armida, Alessia Butera, Antonella Pezzola, Laura Ricceri (Rome)
P331
Release-regulating sphingosine-1-phosphate receptors in nerve endings and glial particles of mice central nervous system
Alessandra Roggeri, Matteo Vergassola, Francesca Cisani, Guendalina Olivero, Francesco Minetti, Anna Pittaluga (Genoa)
P332
Effect of non-psychotropic Cannabis sativa L. extract on LPS-induced microglial response
Giovanna Rigillo1 , Vittoria Borgonetti2 , Cristina Benatti1 , Paolo Governa3 , Fabio Tascedda1 , Marco Biagi3 ( 1 Modena, 2 Florence, 3 Siena)
P333
Peripubertal cannabidiol treatment counteracts behavioral and molecular alterations induced by perinatal delta-9-tetrahydrocannabinol exposure
Samuele Laudani1 , Tibor Stark2 , Fabio A. Iannotti3 , Oriana Maurel1 , Giovanni Giurdanella1 , Martina Di Bartolomeo4 , Martin Kuchar5 , Claudio D’Addario4 , Salvatore Salomone1 , Raphael Mechoulam6 , Filippo Drago1 , Alexandra Sulcova2 , Vincenzo Di M
P334
Impact of endocannabinod system modulation on adolescent brain maturation
Cristina Manenti1 , Pamela Prini1 , Daniela Parolaro2 , Tiziana Rubino1 ( 1 Varese, 2 Milan)
P335
Preclinical and clinical evidence for a distinct regulation of mu opioid and type 1 cannabinoid receptor genes expression in obesity
Claudio D’Addario1 , Maria Vittoria Micioni Di Bonaventura2 , Mariangela Pucci1 , Valeria Vezzoli3 , Elizabeta Zaplatic1 , Marcella Massimini1 , Stefania Mai3 , Alessandro Sartorio3 , Emanuela Micioni Di Bonaventura2 , Massimo Scacchi3 , Luca Persani3 ,
P336
Long exposure to high palatable food on pain sensitivity: role of cannabinergic system
Carmen Avagliano1 , Maria Vittoria Micioni Di Bonaventura2 , Maria Elena Giusepponi2 , Carmen De Caro1 , Claudia Cristiano1 , Giovanna La Rana1 , Adele Romano3 , Antonio Calignano1 , Silvana Gaetani3 , Roberto Russo1 , Carlo Cifani2 ( 1 Naples, 2 Camerino
P337
Role of the basolateral amygdala in the hippocampal endocannabinoid modulation of fear memory retrieval in rats
Alessia Santori1 , Patrizia Ratano1 , Krista L. Wahlstrom2 , Ryan T. LaLumiere2 , Patrizia Campolongo1 ( 1 Rome, 2 Iowa City - USA)
P338
Fluoxetine as a precision medicine approach in epileptic encephalopathies caused by gain-of-function mutations in KCNC1 channels
Paolo Ambrosino1 , Maria Virginia Soldovieri2 , Ilaria Mosca2 , Francesca Ragona3 , Tiziana Granata3 , Cinzia Gellera3 , Jacopo Di Francesco3 , Barbara Castellotti3 , Lorella Maria Teresa Canzoniero1 , Maurizio Taglialatela4 ( 1 Benvento, 2 Campobasso, 3
P339
Kv7 activators as targeted therapies for epileptic encephalopathy caused by Kv7.2 mutations
Ilaria Mosca1 , Maria Virginia Soldovieri1 , Paolo Ambrosino2 , Elena Freri3 , Barbara Castellotti3 , Cinzia Gellera3 , Jacopo Di Francesco3 , Gaetan Lesca4 , Maurizio Taglialatela5 ( 1 Campobasso, 2 Benevento, 3 Milan, 4 Lyon - France, 5 Naples)
P340
Cognitive impairment in the Wistar Albino Glaxo/Rij-rat (WAG/Rij) absence model is secondary to absence seizures and depressive-like behavior
Antonio Leo, Martina Tallarico, Luigi Francesco Iannone, Carmen De Caro, Rita Citraro, Emilio Russo, Giovambattista De Sarro (Catanzaro)
P341
Metabolic alterations predispose to epilepsy in High Fat Diet treated mice
Valentina Nesci, Biagio Arcidiacono, Rita Citraro, Antonio Leo, Emilio Russo, Antonio Brunetti, Giovambattista De Sarro (Catanzaro)
P342
Perampanel is effective as add-on therapy in drug-resistant temporal lobe epilepsy with or without hippocampal sclerosis
Luigi Francesco Iannone, Angelo Labate, Edoardo Ferlazzo, Roberta Roberti, Antonio Gambardella, Umberto Aguglia, Giovambattista De Sarro, Emilio Russo (Catanzaro)
P343
Molecular and functional consequences of a novel variant in the KCNQ3 gene found in a proband with neonatal-onset seizures and non-syndromic intellectual disability
Anna Lauritano1 , Sebastien Moutton2 , Elena Longobardi1 , Frédéric TranMau-Them2 , Giusy Laudati1 , Mario Nappi1 , Piera Nappi1 , Maria Virginia Soldovieri3 , Paolo Ambrosino4 , Mauro Cataldi1 , Thibaud Jouan2 , Daphné Lehalle2 , Hélène Maurey5 , Ch
P344
Investigating the modulatory activity of the novel drug SEP-363856 in the phencyclidine model of schizophrenia
Alice Sanson1 , Veronica Begni1 , Ben Grayson2 , Joanna Neill2 , Marco Andrea Riva1 ( 1 Milan, 2 Manchester - United Kingdom)
P345
Pharmacokinetics of paliperidone in patients with schizophrenia: comparison between oral and long-acting injection formulations
Vincenza Santoro1 , Edoardo Spina1 , Antonio Bruno1 , Sara Baldelli2 , Emilio Clementi2 , Dario Cattaneo2 ( 1 Messina, 2 Milan)
P346
MDMA exposure induces BDNF and HDAC I alterations: possible correlation with later neuropsychiatric disorders
Serena Stamatakos, Francesca Felicia Caputi, Laura Rullo, Sanzio Candeletti, Patrizia Romualdi (Bologna)
P347
Role of maternal immune activation in neurodevelopmental disorders and possible pharmacological treatment
Francesca Aria, Andrea Mastinu, Giuseppina Maccarinelli, Marika Premoli, Maurizio Memo, Sara Anna Bonini (Brescia)
P348
In vivo electrophysiological and microdialysis study of dopamine transporter inhibitors R-modafinil and its analogue CE-123
inhibitors R-modafinil and its analogue CE-123 Claudia Sagheddu1 , Nicholas Pintori1 , Gessica Piras1 , Predrag Kalaba2 , Vladimir Draga
P349
Irisin levels in fast and slow twich muscles are differently modified in socially isolated rats
Giulia Maria Camerino1 , Elena Conte1 , Maria Grazia Morgese2 , Stefania Schiavone2 , Luigia Trabace2 ( 1 Bari, 2 Foggia)
P350
How have intravitreal anti-VEGF and dexamethasone implant been used in Italy? A multi-regional, population-based study in 2010-2016
Italy? A multi-regional, population-based study in 2010-2016 Giulia Scondotto1 , Janet Sultana1 , Valentina Ientile1 , Ylenia Ingrasciotta1 , Andrea Fontana2 , Eliana Mirabelli1 , Costantino Jonh Trombetta1 , Carlo Rapisarda3 , Teresio Avitabile3 , Antoni
P351
High risk of cardiovascular events in general practice: a focus on patients’ management in Sicily
Michelangelo Rottura, Maria Antonietta Barbieri, Giuseppe Cicala, Sebastiano Marino, Francesco Squadrito, Vincenzo Arcoraci (Messina)
P352
Intravitreal anti-vascular endothelial growth factor drugs and risk of serious non-ocular bleeding
Janet Sultana1 , Francesco Giorgianni1 , Giulia Scondotto1 , Valentina Ientile1 , Pasquale Cananzi2 , Olivia Leoni3 , Sebastiano Pollina Addario2 , Giovanbattista De Sarro4 , Adele de Francesco4 , Maria Rosaria Puzo5 , Christel Renoux6 , Gianluca Trifirò
P353
Pattern of use and safety profile of branded vs generic antiepileptic drugs
Sabrina Giometto1,2, Rosa Gini2 , Eleonora Cei2 , Laura Baglietto1 , Alfredo Vannacci2 , Alessandra Bettiol2 , Marco Tuccori1 , Alessandro Mugelli2 , Ersilia Lucenteforte1 ( 1Pisa, 2 Florence)
P354
Gender differences in the management of chronic obstructive pulmonary disease: effect of a clinical audit in a Sicilian general practice setting
Valentina Isgrò1 , Janet Sultana1 , Valentina Ientile1 , Andrea Fontana2 , Umberto Alecci1 , Riccardo Scoglio1 , Francesco Magliozzo1 , Gianluca Trifirò1 ( 1 Messina, 2 Foggia)
P355
Antibiotic prescribing in Internal Medicine Units of an Italian tertiary care hospital: an observational study
Pietro Nunnari, Fabrizio Colombo, Giovanni Ceccarelli, Angelo Valerio Romano, Francesco Scaglione (Milan)
P356
PREemptive pharmacogenomic testing for Preventing Adverse drug Reactions (PREPARE): state of art and preliminary results on genotype actionability
(PREPARE): state of art and preliminary results on genotype actionability Francesco Comello1 , Lisa Dal Cin1 , Alessia Bignucolo1 , Silvia Mezzalira1 , Rossana Roncato1 , Tania Di Raimo1 , Francesco Angelini1 , Viola Cappato1 , Franca Sartor1 , Luisa Folt
P358
AR-V7 and AR-FL expression is associated with clinical outcome: a translational study in patients with castrate resistant prostate cancer
Stefania Crucitta1 , Marzia Del Re1 , Andrea Sbrana1 , Eleonora Rofi1 , Federico Paolieri1 , Luca Galli1 , Alfredo Falcone1 , Riccardo Morganti1 , Camillo Porta2 , Eleni Efstathiou3 , Ron van Schaik4 , Guido Jenster4 , Romano Danesi1 ( 1 Pisa, 2 Pavia, 3
P359
Pharmacogenetics profiling of transplanted patients taking tacrolimus reveals that allelic mutations have a strong correlation with altered plasma levels
that allelic mutations have a strong correlation with altered plasma levels Giovanni Pallio, Alessandra Bitto, Letteria Minutoli, Natasha Irrera, Federica Mannino, Domenica Altavilla, Vincenzo Arcoraci, Michelangelo Rottura, Francesco Squadrito (Messina)
P360
Application of therapeutic drug monitoring in pediatric intensive care unit: a case report
R. Simeoli, M. Marano, E. Agolini, D. Cocciadiferro, M. Dionisi, S. Cairoli, M. Tarchi, V. Ventura, B.M. Goffredo (Rome)
P362
Potassium channels as pharmacological target for the treatment of Congenital Central Hypoventilation Syndrome
Silvia Cardani, Simona Di Lascio, Lara Pizzamiglio, Flavia Antonucci, Roberta Benfante, Diego Fornasari (Milan)
P363
Alcohol consumption during pregnancy induces altered transcriptional regulation in mothers and offspring partially counteracted by environment enrichment
Fabio Bellia1 , Aranza Wille-Bille2 , Mariangela Pucci1 , Sebastian MirandaMorales2 , Ricardo Marcos Pautassi2 , Claudio D’Addario1 ( 1 Teramo, 2 Còrdoba - Argentina)
P365
Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/ DREAM/PDYN pathway
Giusy Laudati1 , Luigi Mascolo1 , Natascia Guida1 , Rossana Sirabella1 , Vincenzo Pizzorusso1 , Sara Bruzzaniti1 , Angelo Serani1 , Gianfranco Di Renzo1 , Lorella M.T. Canzoniero2 , Luigi Formisano1 (1 Naples, 2 Benevento)
P366
Herpes zoster among patients at risk: epidemiology, healthcare resources utilization and costs from a large Italian real-world database
Silvia Calabria1 , Giulia Ronconi1 , Letizia Dondi1 , Carlo Piccinni1 , Antonella Pedrini1 , Immacolata Esposito2 , Pierluigi Viale3 , Nello Martini1 ( 1 Casalecchio di Reno, 2 Rome, 3 Bologna)
P367
HR+/HER2- metastatic breast cancer in a large Italian database: incidence, prescription patterns, disease progression and direct costs
Carlo Piccinni1 , Giulia Ronconi1 , Silvia Calabria1 , Letizia Dondi1 , Antonella Pedrini1 , Immacolata Esposito2 , Nello Martini1 , Maurizio Marangolo1 ( 1 Casalecchio di Reno, 2 Rome)
P368
Re-use of routinely collected electronic healthcare data for the execution of real-world studies on the utilization o
Andrea Spini1 , Giulia Hyeraci2 , Francesco Pellicano1 , Sandra Donnini1 , Silvano Giorgi1 , Claudia Bartolini2 , Rosa Gini2 , Marina Ziche1 , Giuseppe Roberto2 ( 1 Siena, 2 Florence)
P369
Drug-utilization pattern of non small cell lung cancer patients analyzed by gender at University Hospital of Siena, Italy (UHS)
Pietro Rosellini1 , Andrea Spini1 , Giuseppe Roberto2 , Rosa Gini2 , Valerio Ciccone1 , Edoardo Francini3 , Alessandra Pascucci1 , Sandra Donnini1 , Marina Ziche1 ( 1 Siena, 2 Florence, 3 Grosseto)
P370
P371 Prevalence of statin-associated muscle symptoms in Italy: the PROSISA study
Federica Bonaiti1 , Manuela Casula1 , Marta Gazzotti1 , Elena Olmastroni1 , Liliana Grigore2 , Alberico Luigi Catapano1 ( 1 Milan, 2 Sesto S. Giovanni)
P371
Switching from infliximab-originator to infliximab-biosimilar in rheumatologic patients: the clinical impact in Tuscan Region
Irma Convertino1 , Ersilia Lucenteforte1 , Marta Mosca1 , Giuseppe Turchetti1 , Valentina Lorenzoni1 , Leopoldo Trieste1 , Sara Ferraro1 , Luca Leonardi1 , Giuseppe Roberto2 , Nicoletta Luciano1 , Corrado Blandizzi1 , Rosa Gini2 , Marco Tuccori1 ( 1 Pisa,
P372
Real World Data on the utilization pattern and safety profile of infliximab originator versus biosimilars in Italy: a multiregional study
Federica Fraenza1 , Cristina Scavone1 , Maurizio Sessa1 , Emilio Clementi2 , Giovanni Corrao2 , Roberto Leone3 , Alessandro Mugelli4 , Francesco Rossi1 , Edoardo Spina5 , Annalisa Capuano1 ( 1 Naples, 2 Milan, 3 Verona, 4 Florence, 5 Messina)
P373
Sex differences in factors associated with adherence to statin therapy: a population-based stud
Elena Olmastroni, Elena Tragni, Federico Rea, Luca Merlino, Giovanni Corrao, Alberico L. Catapano, Manuela Casula (Milan)
P374
Immune-related adverse drug reactions associated to immune checkpoint inhibitors: data from the Italian spontaneous reporting system
Rosanna Ruggiero, Federica Fraenza, Mario Gaio, Alessia Zinzi, Anna Larato, Carmen Ferrajolo, Liberata Sportiello, Concetta Rafaniello, Liberato Berrino, Annalisa Capuano (Naples)
P375
Drugs-induced pathological gambling: an analysis of italian spontaneous reporting system
Barbara Stelitano, Cristina Scavone, Mario Gaio, Alessia Zinzi, Federica Fraenza, Anna Larato, Angela Falco, Concetta Rafaniello, Liberata Sportiello, Annalisa Capuano (Naples)
P376
Gender differences in outpatient pediatric drug utilization: a cohort study from Southern Italy
Alessia Zinzi1 , Carmen Ferrajolo1 , Janet Sultana2 , Valentina Ientile1 , Cristina Scavone1 , Giulia Scondotto2 , Michele Tari3 , Gianluca Trifirò2 , Annalisa Capuano1 ( 1 Naples, 2 Messina, 3 Caserta)
P377
Aripiprazole and risperidone in pediatric population, an update of safety issues and focus on off-label use: an analysis of the European pharmacovigilance database (EudraVigilance) from 2016 to 2018
Simona Brusco, Michele Bertini, Cristina Scavone, Carmen Ferrajolo, Liberata Sportiello, Maria Giuseppa Sullo, Eleonora Landolfi, Pasquale Maria Berrino, Annalisa Capuano, Concetta Rafaniello (Naples
P378
Pharmacovigilance in SPA medicine
Maria Costantino1 , Valeria Conti1 , Teresa Iannaccone1 , Francesco Marongiu2 , Valentina Manzo1 , Mario Farroni1 , Amelia Filippelli1 ( 1 Salerno, 2 Naples)
P379
Causality and severity assessment of adverse events in paediatric clinical trials: a literature review of available tools
Mariagrazia Felisi1 , Cristina Manfredi1 , Louise Braken2 , Matthew Peak2 , Mark Turner2 , Adriaca Ceci3 , Donato Bonifazi1 ( 1 Pavia, 2 Liverpool - United Kingdom, 3 Valenzano)
P380
Glycyrrhizic Acid attenuates the cytotoxicity induced by high glucose in neuroblastoma cell line
Laura Ciarlo, Francesca Marzoli, Paola Minosi, Amalia Di Giannuario, Paola Matarrese, Stefano Pieretti (Rome)
P381
A new HPLC-UV method compared with HPLC-MS for daptomycin levels in human plasma samples
Giacomo Luci, Federico Cucchiara, Marianna Lastella, Laura Ciofi, Romano Danesi, Antonello Di Paolo (Pisa)
P382
Prevalence of familial hypercholesterolaemia (FH) in Italian Patients with coronary artery disease: the POSTER Study
Veronica Zampoleri1 , Andrea Baragetti1 , Marco Gorini2 , Gianna Fabbri2 , Andrea Lorimer2 , Donata Lucci2 , Michele Massimo Gulizia2 , Aldo Pietro Maggioni2 , Alberico Luigi Catapano1 (1 Milan, 2 Florence)
P383
Dietary supplementation with a peculiar amino acid formula sustains mitochondrial bioenergetics and reduces hepatic damage in a mouse model of non-alcoholic fatty liver disease
Emanuela Bottani1 , Agnese Segala1 , Silvia Marconi1 , Dario Brunetti2 , Fabio Rossi2 , Marika Vezzoli1 , Enzo Nisoli2 , Alessandra Valerio1 ( 1 Brescia, 2 Milan)
P384
A dried blood spot microsampling-liquid chromatography tandem mass spectrometry method for therapeutic drug monitoring of phenobarbital in newborns
Marine Pingeon, Maria Viviana Olimpia Fortunato, Antonio Di Donna, Maria Corbo, Amelia Filippelli, Viviana Izzo, Fabrizio Dal Piaz (Salerno)
P385
Translational science to support paediatric clinical research - The European Paediatric Translational Research Infrastructure experience
Lucia Ruggieri1 , Donato Bonifazi2 , Annalisa Landi1 , Mariangela Lupo3 , Antje Neubert4 , Cristina Calvo5 , Emmanuel Mikros6 , Hana Kubova7 , Marialuisa Lavitrano8 , Marina Kleanthous9 , Saskia de Wildt10, Tessa van der Geest10, Evelyne Jacqz-Aigrain11,
P386